Gabbr2 gamma-aminobutyric acid type B receptor subunit 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gabbr2provided by RGD
Official Full Name: gamma-aminobutyric acid type B receptor subunit 2provided by RGD
Primary source: RGD:619864
See related: EnsemblRapid:ENSRNOG00000008431 AllianceGenome:RGD:619864
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gpr51
Summary: Enables G protein-coupled GABA receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; gamma-aminobutyric acid signaling pathway; and neuron-glial cell signaling. Is active in GABA-ergic synapse; glutamatergic synapse; and synaptic membrane. Biomarker of nicotine dependence. Human ortholog(s) of this gene implicated in alcohol use disorder; developmental and epileptic encephalopathy 59; and nicotine dependence. Orthologous to human GABBR2 (gamma-aminobutyric acid type B receptor subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 187.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 5q22

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (65743073..66083695, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (60947517..61288104, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (62276100..62621737, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Natural Product Isoliquiritigenin Activates GABAB Receptors to Decrease Voltage-Gate Ca(2+) Channels and Glutamate Release in Rat Cerebrocortical Nerve Terminals.
Title: Natural Product Isoliquiritigenin Activates GABA(B) Receptors to Decrease Voltage-Gate Ca(2+) Channels and Glutamate Release in Rat Cerebrocortical Nerve Terminals.
Study provided evidence that GABAB2 subunit is involved in anxiety-like behaviours induced by chronic cerebral hypoperfusion. Activation of GABAB2 subunits could improve BDNF/TrkB/NCAM signalling and reverse Kir3 channel surface expressions in hippocampal CA1, which may alleviate the anxiety-like behaviours in rats with chronic cerebral hypoperfusion.
Title: Activation of GABAB2 subunits alleviates chronic cerebral hypoperfusion-induced anxiety-like behaviours: A role for BDNF signalling and Kir3 channels.
this study shows that the trafficking and surface expression of GABABR2 and GABABR1 is differentially regulated by synaptic or pathophysiological activation of NMDA receptors.
Title: Differential regulation of GABAB receptor trafficking by different modes of N-methyl-D-aspartate (NMDA) receptor signaling.
Gabbr2 exists in rat brain at birth and decreases between birth and PD15.
Title: Plasma membrane density of GABA(B)-R1a, GABA(B)-R1b, GABA-R2 and trimeric G-proteins in the course of postnatal development of rat brain cortex.
siRNA knock-down of NgR1 resulted in a selective increase of GABAB R1 and GABAB R2 protein and an increase in GIRK1.
Title: Post-transcriptional regulation of GABAB receptor and GIRK1 channels by Nogo receptor 1.
GABABR activation reduces cyclic AMP-dependent phosphorylation of LKB1, a kinase involved in neuronal polarization, and rescues LKB1 overexpression-induced defects in cortical development.
Title: Non-hyperpolarizing GABAB receptor activation regulates neuronal migration and neurite growth and specification by cAMP/LKB1.
GABA(B)R2 proteins are reduced in the prefrontal cortex of aged rats but these reductions are not associated with spatial learning abilities.
Title: GABA(B) receptor GTP-binding is decreased in the prefrontal cortex but not the hippocampus of aged rats.
Loss of GABA(B) receptors on primary afferent neurons may contribute to the development of mechanical allodynia after L5 spinal nerve ligation.
Title: Spinal nerve ligation decreases γ-aminobutyric acidB receptors on specific populations of immunohistochemically identified neurons in L5 dorsal root ganglion of the rat.
Regional distribution of GABABR2 in auditory neurons matches their inputs; the cellular localization of GABABR2 in auditory neurons fits the synaptic responses in these cells.
Title: The level and distribution of the GABA(B)R2 receptor subunit in the rat's central auditory system.
Adult stem cells from rat adipose tissue or bone marrow were found to express GABA-B2 receptor subunits. GABA-B receptors in differentiated adipose tissue stem cells are functionally active, regulating a key process such as proliferation.
Title: Schwann-like adult stem cells derived from bone marrow and adipose tissue express γ-aminobutyric acid type B receptors.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU049025 (e-PCR)
- UniSTS:145473

D5Wox44 (e-PCR)
- UniSTS:518982

Gabbr2 (e-PCR), detects polymorphism
- UniSTS:525646

RH142538 (e-PCR)
- UniSTS:231785

BF399143 (e-PCR)
- UniSTS:247543

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled GABA receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled GABA receptor activity	IEA Inferred from Electronic Annotation more info
contributes_to G protein-coupled GABA receptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in gamma-aminobutyric acid signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in gamma-aminobutyric acid signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in gamma-aminobutyric acid signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in gamma-aminobutyric acid signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in neuron-glial cell signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in synaptic transmission, GABAergic	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of G protein-coupled GABA receptor complex	IEA Inferred from Electronic Annotation more info
part_of G protein-coupled GABA receptor complex	ISO Inferred from Sequence Orthology more info
part_of G protein-coupled receptor heterodimeric complex	IBA Inferred from Biological aspect of Ancestor more info
part_of G protein-coupled receptor heterodimeric complex	IEA Inferred from Electronic Annotation more info
part_of G protein-coupled receptor heterodimeric complex	ISO Inferred from Sequence Orthology more info
part_of G protein-coupled receptor heterodimeric complex	ISS Inferred from Sequence or Structural Similarity more info
part_of GABA receptor complex	ISO Inferred from Sequence Orthology more info
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: gamma-aminobutyric acid type B receptor subunit 2

Names: G-protein coupled receptor 51; GABA-B R2 receptor; GABA-B receptor 2; GABA-B-R2; GABA-BR2; GABABR2; gamma-aminobutyric acid (GABA) B receptor 2; gb2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031802.2 → NP_113990.2 gamma-aminobutyric acid type B receptor subunit 2 precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

O88871, Q9JK36, Q9QWU2

UniProtKB/TrEMBL

A0A0A0MXV8

Related

ENSRNOP00000011573.5, ENSRNOT00000011573.6

Conserved Domains (3) summary

cd15294
Location:479 → 748

7tmC_GABA-B-R2; gamma-aminobutyric acid type B receptor subunit 2, member of the class C family of seven-transmembrane G protein-coupled receptors

pfam18455
Location:778 → 816

GBR2_CC; Gamma-aminobutyric acid type B receptor subunit 2 coiled-coil domain

cd06366
Location:57 → 459

PBP1_GABAb_receptor; ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)