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    Kcnb2 potassium voltage-gated channel subfamily B member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117105, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kcnb2provided by RGD
    Official Full Name
    potassium voltage-gated channel subfamily B member 2provided by RGD
    Primary source
    RGD:621349
    See related
    EnsemblRapid:ENSRNOG00000028991 AllianceGenome:RGD:621349
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kv2.2
    Summary
    Enables delayed rectifier potassium channel activity; protein heterodimerization activity; and transmembrane transporter binding activity. Involved in potassium ion transmembrane transport and protein localization to plasma membrane. Located in dendrite and neuronal cell body membrane. Part of voltage-gated potassium channel complex. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human KCNB2 (potassium voltage-gated channel subfamily B member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 66.9), Uterus (RPKM 31.6) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Kcnb2 in Genome Data Viewer
    Location:
    5q11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (8340085..8811184, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (3567012..4028564, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (2975934..3430837, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486909 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC134487099 Neighboring gene uncharacterized LOC102555640

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables delayed rectifier potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables delayed rectifier potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in potassium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of voltage-gated potassium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    potassium voltage-gated channel subfamily B member 2
    Names
    CDRK
    potassium channel, voltage gated Shab-related subfamily B, member 2
    potassium voltage gated channel, Shab-related subfamily, member 2
    voltage-gated potassium channel subunit Kv2.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_054000.2NP_446452.2  potassium voltage-gated channel subfamily B member 2

      See identical proteins and their annotated locations for NP_446452.2

      Status: PROVISIONAL

      Source sequence(s)
      CH473984
      UniProtKB/Swiss-Prot
      Q63099
      UniProtKB/TrEMBL
      A6JFC3, F1LVV2
      Conserved Domains (3) summary
      cd18412
      Location:19145
      BTB_POZ_KCNB2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily B member 2 (KCNB2)
      pfam00520
      Location:192428
      Ion_trans; Ion transport protein
      pfam03521
      Location:471755
      Kv2channel; Kv2 voltage-gated K+ channel

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      8340085..8811184 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287085.1XP_063143155.1  potassium voltage-gated channel subfamily B member 2 isoform X1

      UniProtKB/Swiss-Prot
      Q63099
      UniProtKB/TrEMBL
      A6JFC3, F1LVV2
      Related
      ENSRNOP00000050431.3, ENSRNOT00000045460.4