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    Nradd neurotrophin receptor associated death domain [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246143, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nraddprovided by RGD
    Official Full Name
    neurotrophin receptor associated death domainprovided by RGD
    Primary source
    RGD:708524
    See related
    EnsemblRapid:ENSRNOG00000020936 AllianceGenome:RGD:708524
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    NRH2; PLAIDD
    Summary
    Enables neurotrophin p75 receptor binding activity. Involved in in utero embryonic development. Located in cell body membrane and neuron projection membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 43.4), Adrenal (RPKM 36.1) and 9 other tissues See more
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    Genomic context

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    See Nradd in Genome Data Viewer
    Location:
    8q32
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (119478055..119481336, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (110599667..110603068, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (118890402..118893712, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene kinesin family member 9 Neighboring gene SET domain containing 2, histone lysine methyltransferase Neighboring gene uncharacterized LOC108351781 Neighboring gene neurobeachin-like 2 Neighboring gene coiled-coil domain containing 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NRADD, a novel membrane protein with a death domain involved in mediating apoptosis in response to ER stress. Wang X, et al. Cell Death Differ, 2003 May. PMID 12728256
    2. PLAIDD, a type II death domain protein that interacts with p75 neurotrophin receptor. Frankowski H, et al. Neuromolecular Med, 2002. PMID 12095158
    3. Release of a membrane-bound death domain by gamma-secretase processing of the p75NTR homolog NRADD. Gowrishankar K, et al. J Cell Sci, 2004 Aug 15. PMID 15280425
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables coreceptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables death receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nerve growth factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neurotrophin p75 receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in in utero embryonic development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell body membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuron projection membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope lumen ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    death domain-containing membrane protein NRADD
    Names
    neurotrophin receptor homolog-2
    neurotrophin receptor-alike death domain protein
    p75-like apoptosis-inducing death domain protein PLAIDD

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139259.2 → NP_640352.1  death domain-containing membrane protein NRADD

      See identical proteins and their annotated locations for NP_640352.1

      Status: PROVISIONAL

      Source sequence(s)
      AF497263
      UniProtKB/Swiss-Prot
      G3V8U7, Q8K5A8, Q8K5A9
      Related
      ENSRNOP00000112382.1, ENSRNOT00000140942.1
      Conserved Domains (1) summary
      cd08311
      Location:138 → 219
      Death_p75NR; Death domain of p75 Neurotrophin Receptor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      119478055..119481336 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243921.4 → XP_006243983.1  death domain-containing membrane protein NRADD isoform X1

      See identical proteins and their annotated locations for XP_006243983.1

      UniProtKB/TrEMBL
      A6I3F1, A6I3F2
      Conserved Domains (1) summary
      cd08311
      Location:89 → 170
      Death_p75NR; Death domain of p75 Neurotrophin Receptor
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K5A9.2 GenPept UniProtKB/Swiss-Prot:Q8K5A9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.