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    Mta2 metastasis associated 1 family, member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361724, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mta2provided by RGD
    Official Full Name
    metastasis associated 1 family, member 2provided by RGD
    Primary source
    RGD:1306743
    See related
    EnsemblRapid:ENSRNOG00000019913 AllianceGenome:RGD:1306743
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables histone deacetylase binding activity. Involved in regulation of fibroblast migration. Predicted to be located in chromosome, telomeric region and nucleus. Predicted to be part of NuRD complex. Predicted to be active in nucleoplasm. Orthologous to human MTA2 (metastasis associated 1 family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 368.7), Spleen (RPKM 354.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mta2 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (215267286..215276008)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (205838181..205846903)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (225140863..225149584)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene retinal outer segment membrane protein 1 Neighboring gene EMAP like 3 Neighboring gene terminal uridylyl transferase 1, U6 snRNA-specific Neighboring gene uncharacterized LOC134483968 Neighboring gene eukaryotic translation elongation factor 1 gamma

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of mouse metastasis-associated gene 2: genomic structure, nuclear localization signal, and alternative potentials as transcriptional activator and repressor. Matsusue K, et al. DNA Cell Biol, 2001 Oct. PMID 11749719
    2. Colocalization of metastasis-associated proteins 1/2 and estrogen receptor alpha in rat epididymis. Cheng P, et al. Tissue Cell, 2017 Oct. PMID 28789814
    3. P300 binds to and acetylates MTA2 to promote colorectal cancer cells growth. Zhou J, et al. Biochem Biophys Res Commun, 2014 Feb 14. PMID 24468085
    4. GATA-binding protein-3 regulates T helper type 2 cytokine and ifng loci through interaction with metastasis-associated protein 2. Hwang SS, et al. Immunology, 2010 Sep. PMID 20636338, Free PMC Article
    5. Members of the NuRD chromatin remodeling complex interact with AUF1 in developing cortical neurons. Lee C, et al. Cereb Cortex, 2008 Dec. PMID 18413351, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MTA1 and MTA2 may be involved in the regulation of ERalpha transactivation activity in the epididymis of rats to facilitate a stable environment in the lumen
      Title: Colocalization of metastasis-associated proteins 1/2 and estrogen receptor alpha in rat epididymis.
    2. endogenous Mta1/2 forms a complex with Chd4, Hdac1/2, RbAp48, and Mbd3 in the rat cerebellum
      Title: Promoter decommissioning by the NuRD chromatin remodeling complex triggers synaptic connectivity in the mammalian brain.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone deacetylase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within genomic imprinting ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of fibroblast migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NuRD complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NuRD complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of histone deacetylase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    metastasis-associated protein MTA2
    Names
    metastasis-associated gene family, member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100740.1 → NP_001094210.1  metastasis-associated protein MTA2

      See identical proteins and their annotated locations for NP_001094210.1

      Status: PROVISIONAL

      Source sequence(s)
      BC166471
      UniProtKB/TrEMBL
      B2GV01, F7F888
      Related
      ENSRNOP00000027141.7, ENSRNOT00000027141.7
      Conserved Domains (5) summary
      cd11661
      Location:267 → 312
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      smart00401
      Location:363 → 413
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd04709
      Location:3 → 168
      BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
      pfam01448
      Location:147 → 198
      ELM2; ELM2 domain
      pfam17226
      Location:449 → 524
      MTA_R1; MTA R1 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      215267286..215276008
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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