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    Pianp PILR alpha associated neural protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312711, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pianpprovided by RGD
    Official Full Name
    PILR alpha associated neural proteinprovided by RGD
    Primary source
    RGD:1304952
    See related
    EnsemblRapid:ENSRNOG00000017052 AllianceGenome:RGD:1304952
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PANP; leda-1; RGD1304952
    Summary
    Predicted to enable protein domain specific binding activity. Predicted to be involved in regulation of immune response. Predicted to act upstream of or within several processes, including brain development; glutamate secretion; and visual learning. Located in basolateral plasma membrane. Orthologous to human PIANP (PILR alpha associated neural protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 10.9), Adrenal (RPKM 10.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pianp in Genome Data Viewer
    Location:
    4q42
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (159482678..159491085)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (157796425..157804842)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (157508862..157517676)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene COP9 signalosome subunit 7A Neighboring gene uncharacterized LOC120102387 Neighboring gene zinc finger protein 384 Neighboring gene uncharacterized LOC102554095 Neighboring gene inhibitor of growth family, member 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Liver sinusoidal endothelium: a microenvironment-dependent differentiation program in rat including the novel junctional protein liver endothelial differentiation-associated protein-1. Géraud C, et al. Hepatology, 2010 Jul. PMID 20578158
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cerebellum development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cerebellum development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dentate gyrus development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within dentate gyrus development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in gamma-aminobutyric acid signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glutamate secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glutamate secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in homeostasis of number of cells IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within homeostasis of number of cells ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in social behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within social behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in visual learning IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within visual learning ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    PILR alpha-associated neural protein
    Names
    PILR-associating neural protein
    liver endothelial differentiation-associated protein-1
    paired immunoglobin-like type 2 receptor-associating neural protein
    uncharacterized protein C12orf53 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014059.1 → NP_001014081.1  PILR alpha-associated neural protein precursor

      See identical proteins and their annotated locations for NP_001014081.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085924
      UniProtKB/Swiss-Prot
      Q5U2P6
      UniProtKB/TrEMBL
      A6ILP0
      Related
      ENSRNOP00000060404.2, ENSRNOT00000065846.4
      Conserved Domains (1) summary
      pfam15298
      Location:191 → 232
      AJAP1_PANP_C; AJAP1/PANP C-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      159482678..159491085
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107681.2 → XP_038963609.1  PILR alpha-associated neural protein isoform X2

      UniProtKB/TrEMBL
      A0A8I6AV41, A6ILN7

    2. XM_039107680.2 → XP_038963608.1  PILR alpha-associated neural protein isoform X2

      UniProtKB/TrEMBL
      A0A8I6AV41, A6ILN7

    3. XM_008763286.4 → XP_008761508.1  PILR alpha-associated neural protein isoform X2

      See identical proteins and their annotated locations for XP_008761508.1

      UniProtKB/TrEMBL
      A0A8I6AV41, A6ILN7
      Related
      ENSRNOP00000097907.1, ENSRNOT00000099374.2
      Conserved Domains (1) summary
      pfam15298
      Location:191 → 232
      AJAP1_PANP_C; AJAP1/PANP C-terminus

    4. XM_017592652.3 → XP_017448141.1  PILR alpha-associated neural protein isoform X2

      UniProtKB/TrEMBL
      A0A8I6AV41, A6ILN7
      Conserved Domains (1) summary
      pfam15298
      Location:191 → 232
      AJAP1_PANP_C; AJAP1/PANP C-terminus

    5. XM_008763285.4 → XP_008761507.1  PILR alpha-associated neural protein isoform X1

      Conserved Domains (1) summary
      pfam15298
      Location:240 → 281
      AJAP1_PANP_C; AJAP1/PANP C-terminus

    6. XM_006237370.5 → XP_006237432.1  PILR alpha-associated neural protein isoform X2

      See identical proteins and their annotated locations for XP_006237432.1

      UniProtKB/TrEMBL
      A0A8I6AV41, A6ILN7
      Conserved Domains (1) summary
      pfam15298
      Location:191 → 232
      AJAP1_PANP_C; AJAP1/PANP C-terminus
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U2P6.1 GenPept UniProtKB/Swiss-Prot:Q5U2P6

    Gene LinkOut

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