Nfatc3 nuclear factor of activated T-cells 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nfatc3provided by RGD
Official Full Name: nuclear factor of activated T-cells 3provided by RGD
Primary source: RGD:1308692
See related: EnsemblRapid:ENSRNOG00000054264 AllianceGenome:RGD:1308692
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: NFAT4; NFATx
Summary: Enables transcription cis-regulatory region binding activity. Involved in several processes, including positive regulation of cardiac muscle hypertrophy; positive regulation of transcription by RNA polymerase II; and protein import into nucleus. Located in cytoplasm and nucleus. Orthologous to human NFATC3 (nuclear factor of activated T cells 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 452.6), Spleen (RPKM 182.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (50870464..50944992)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (33960643..34035150)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (38039542..38114003)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The transplant rejection response involves neutrophil and macrophage adhesion-mediated trogocytosis and is regulated by NFATc3.
Title: The transplant rejection response involves neutrophil and macrophage adhesion-mediated trogocytosis and is regulated by NFATc3.
MicroRNA153 induces apoptosis by targeting NFATc3 to improve vascular remodeling in pulmonary hypertension.
Title: MicroRNA153 induces apoptosis by targeting NFATc3 to improve vascular remodeling in pulmonary hypertension.
miR-339-3p promotes AT1-AA-induced vascular inflammation by upregulating NFATc3 protein expression in vascular smooth muscle cells.
Title: miR-339-3p promotes AT1-AA-induced vascular inflammation by upregulating NFATc3 protein expression in vascular smooth muscle cells.
Induction of cardiomyocyte calcification is dependent on FoxO1/NFATc3/Runx2 signaling.
Title: Induction of cardiomyocyte calcification is dependent on FoxO1/NFATc3/Runx2 signaling.
MicroRNA153 attenuates hypoxiainduced excessive proliferation and migration of pulmonary arterial smooth muscle cells by targeting ROCK1 and NFATc3.
Title: MicroRNA‑153 attenuates hypoxia‑induced excessive proliferation and migration of pulmonary arterial smooth muscle cells by targeting ROCK1 and NFATc3.
We demonstrate that TRPC3-NFATc3 signaling is modulated by P.E. and critically regulates ventricular CF phenotype and MF. These findings strongly argue for P.E., through TRPC3 targeting, as potential and interesting therapeutics for MF management.
Title: Transient Receptor Potential Canonical 3 and Nuclear Factor of Activated T Cells C3 Signaling Pathway Critically Regulates Myocardial Fibrosis.
AKAP79/150 LZ motif functions to recruit NFAT to the L-type calcium channels signaling complex to promote its activation by AKAP-anchored calcineurin.
Title: AKAP79/150 recruits the transcription factor NFAT to regulate signaling to the nucleus by neuronal L-type Ca(2+) channels.
the activation of TRPV3 aggravated pathological cardiac hypertrophy through calcineurin/NFATc3 signalling pathway and correlated with the protein expression levels of calcineurin, phosphorylated CaMKII and NFATc3, revealing that TRPV3 might be a potential therapeutic target for cardiac hypertrophy.
Title: Activation of transient receptor potential vanilloid 3 channel (TRPV3) aggravated pathological cardiac hypertrophy via calcineurin/NFATc3 pathway in rats.
This study is the first time that radiation-induced activation of NFAT3/c4 has been recorded.
Title: NFAT3/c4-mediated excitotoxicity in hippocampal apoptosis during radiation-induced brain injury.
releases of Ca(2+) from the endoplasmic reticulum (ER), and consequently drives STIM1 aggregation and an inhibitory interaction with LTCCs that increases spine ER content but decreases NFATc3 nuclear translocation.
Title: STIM1 Ca(2+) Sensor Control of L-type Ca(2+)-Channel-Dependent Dendritic Spine Structural Plasticity and Nuclear Signaling.

Submit: New GeneRIF Correction See all GeneRIFs (32)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA850397 (e-PCR)
- UniSTS:261426

D8Ertd281e (e-PCR), detects polymorphism
- UniSTS:167558

Nfatc3 (e-PCR), detects polymorphism
- UniSTS:499101

RH144691 (e-PCR)
- UniSTS:233936

BI280983 (e-PCR)
- UniSTS:249070

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DN4 thymocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in DN4 thymocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within T cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood vessel remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within branching involved in blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in calcineurin-NFAT signaling cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular respiration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to lithium ion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myotube cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myotube differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of vascular associated smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of artery morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of artery morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cardiac muscle hypertrophy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive thymic T cell selection	ISO Inferred from Sequence Orthology more info
involved_in positive thymic T cell selection	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein import into nucleus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of store-operated calcium entry	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to hypoxia	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal muscle fiber development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within thymus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vascular associated smooth muscle cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vascular associated smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: nuclear factor of activated T-cells, cytoplasmic 3

Names: T cell transcription factor NFAT4; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108447.3 → NP_001101917.1 nuclear factor of activated T-cells, cytoplasmic 3 isoform 1

See identical proteins and their annotated locations for NP_001101917.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

A0A8I6AB55, A6IYV7, D3ZU59

Conserved Domains (2) summary

cd07881
Location:422 → 595

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins

cd01178
Location:600 → 700

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
NM_001434582.1 → NP_001421511.1 nuclear factor of activated T-cells, cytoplasmic 3 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/Swiss-Prot

A0A0G2JTY4

UniProtKB/TrEMBL

A0A8I6AB55, A6IYV6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

50870464..50944992

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063278127.1 → XP_063134197.1 nuclear factor of activated T-cells, cytoplasmic 3 isoform X1

UniProtKB/TrEMBL

A0A8I6AB55
XM_063278129.1 → XP_063134199.1 nuclear factor of activated T-cells, cytoplasmic 3 isoform X3

UniProtKB/TrEMBL

A0A8I6AB55

Related

ENSRNOP00000069756.2, ENSRNOT00000089783.3
XM_063278131.1 → XP_063134201.1 nuclear factor of activated T-cells, cytoplasmic 3 isoform X5

UniProtKB/TrEMBL

A0A8I6AB55

Related

ENSRNOP00000102155.1, ENSRNOT00000168212.1
XM_063278128.1 → XP_063134198.1 nuclear factor of activated T-cells, cytoplasmic 3 isoform X2

UniProtKB/TrEMBL

A0A8I6AB55

Related

ENSRNOP00000090103.2, ENSRNOT00000105048.2
XM_063278132.1 → XP_063134202.1 nuclear factor of activated T-cells, cytoplasmic 3 isoform X6

Related

ENSRNOP00000068890.2, ENSRNOT00000087491.3
XM_063278134.1 → XP_063134204.1 nuclear factor of activated T-cells, cytoplasmic 3 isoform X8

UniProtKB/TrEMBL

A0A8I6AB55
XM_063278135.1 → XP_063134205.1 nuclear factor of activated T-cells, cytoplasmic 3 isoform X9

UniProtKB/TrEMBL

A0A8I6AB55

Related

ENSRNOP00000104832.1, ENSRNOT00000133806.1
XM_063278133.1 → XP_063134203.1 nuclear factor of activated T-cells, cytoplasmic 3 isoform X7

UniProtKB/TrEMBL

A0A8I6AB55
XM_063278130.1 → XP_063134200.1 nuclear factor of activated T-cells, cytoplasmic 3 isoform X4

UniProtKB/TrEMBL

A0A8I6AB55
XM_039097850.2 → XP_038953778.1 nuclear factor of activated T-cells, cytoplasmic 3 isoform X8

UniProtKB/TrEMBL

A0A8I6AB55

Conserved Domains (2) summary

cd07881
Location:422 → 595

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins

cd01178
Location:600 → 700

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
XM_039097855.2 → XP_038953783.1 nuclear factor of activated T-cells, cytoplasmic 3 isoform X11

Conserved Domains (3) summary

cd07881
Location:422 → 595

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins

cl15674
Location:600 → 658

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

cl41732
Location:238 → 309

KLF6_7_N-like; N-terminal domain of Kruppel-like factor (KLF) 6, KLF7, and similar proteins
XM_063278136.1 → XP_063134206.1 nuclear factor of activated T-cells, cytoplasmic 3 isoform X10