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    Echdc2 enoyl CoA hydratase domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298381, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Echdc2provided by RGD
    Official Full Name
    enoyl CoA hydratase domain containing 2provided by RGD
    Primary source
    RGD:1308525
    See related
    EnsemblRapid:ENSRNOG00000029333 AllianceGenome:RGD:1308525
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308525
    Summary
    Predicted to enable lyase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to be active in mitochondrion. Orthologous to human ECHDC2 (enoyl-CoA hydratase domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 186.3), Kidney (RPKM 133.1) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Echdc2 in Genome Data Viewer
    Location:
    5q34
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (128144241..128163611)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (122915874..122934860)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (127770570..127789568)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene sterol carrier protein 2 Neighboring gene zyg-11 family member A, cell cycle regulator Neighboring gene basic transcription factor 3, pseudogene 13 Neighboring gene zyg-11 family member B, cell cycle regulator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    enoyl-CoA hydratase domain-containing protein 2, mitochondrial
    Names
    enoyl Coenzyme A hydratase domain containing 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106675.1 → NP_001100145.1  enoyl-CoA hydratase domain-containing protein 2, mitochondrial

      See identical proteins and their annotated locations for NP_001100145.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474008
      UniProtKB/TrEMBL
      A0A8I5ZUZ9, A6JYU2, D3ZIL6
      Related
      ENSRNOP00000049726.3, ENSRNOT00000047653.5
      Conserved Domains (1) summary
      cl23717
      Location:42 → 296
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      128144241..128163611
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287394.1 → XP_063143464.1  enoyl-CoA hydratase domain-containing protein 2, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y213, A0A8I5ZV01
      Related
      ENSRNOP00000082488.1, ENSRNOT00000096852.2

    2. XM_063287395.1 → XP_063143465.1  enoyl-CoA hydratase domain-containing protein 2, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y213, A0A8I5ZV01

    3. XM_039109577.2 → XP_038965505.1  enoyl-CoA hydratase domain-containing protein 2, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZUZ9
      Conserved Domains (1) summary
      cl23717
      Location:45 → 244
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

    4. XM_006238507.3 → XP_006238569.1  enoyl-CoA hydratase domain-containing protein 2, mitochondrial isoform X3

      See identical proteins and their annotated locations for XP_006238569.1

      UniProtKB/TrEMBL
      A6JYU3
      Conserved Domains (1) summary
      cl23717
      Location:1 → 191
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

    RNA

    1. XR_005504398.2 RNA Sequence

    2. XR_005504399.2 RNA Sequence

    3. XR_005504400.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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