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    Vac14 VAC14 component of PIKFYVE complex [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307842, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vac14provided by RGD
    Official Full Name
    VAC14 component of PIKFYVE complexprovided by RGD
    Primary source
    RGD:631410
    See related
    EnsemblRapid:ENSRNOG00000017219 AllianceGenome:RGD:631410
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in phosphatidylinositol biosynthetic process and regulation of postsynaptic neurotransmitter receptor internalization. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be part of PAS complex. Predicted to be active in endosome membrane and presynaptic endosome. Human ortholog(s) of this gene implicated in striatonigral degeneration. Orthologous to human VAC14 (VAC14 component of PIKFYVE complex). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 93.9), Kidney (RPKM 82.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Vac14 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (55499962..55601290)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (38590569..38691911)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (40927007..41029206, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene cap methyltransferase 2 Neighboring gene uncharacterized LOC134483367 Neighboring gene Hydin, axonemal central pair apparatus protein Neighboring gene uncharacterized LOC134483369 Neighboring gene transfer RNA glycine (anticodon GCC) 10 Neighboring gene transfer RNA glycine (anticodon GCC) 9 Neighboring gene uncharacterized LOC134483366 Neighboring gene MTSS I-BAR domain containing 2 Neighboring gene interleukin 34

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Binding of Vac14 to neuronal nitric oxide synthase: Characterisation of a new internal PDZ-recognition motif. Lemaire JF, et al. FEBS Lett, 2006 Dec 22. PMID 17161399
    2. Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex. Sbrissa D, et al. J Biol Chem, 2007 Aug 17. PMID 17556371
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphatidylinositol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of postsynaptic neurotransmitter receptor internalization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of PAS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynaptic endosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein VAC14 homolog
    Names
    Vac14 homolog
    Vac14, PIKFYVE complex component
    vacuole 14 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177930.3 → NP_808791.1  protein VAC14 homolog

      See identical proteins and their annotated locations for NP_808791.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/Swiss-Prot
      Q80W92
      UniProtKB/TrEMBL
      A6IZ63, A6IZ64
      Related
      ENSRNOP00000023383.4, ENSRNOT00000023383.7
      Conserved Domains (3) summary
      pfam11916
      Location:544 → 718
      Vac14_Fig4_bd; Vacuolar protein 14 C-terminal Fig4p binding
      pfam12755
      Location:67 → 163
      Vac14_Fab1_bd; Vacuolar 14 Fab1-binding region
      sd00044
      Location:94 → 122
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      55499962..55601290
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80W92.1 GenPept UniProtKB/Swiss-Prot:Q80W92

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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