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    Dus2 dihydrouridine synthase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291978, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dus2provided by RGD
    Official Full Name
    dihydrouridine synthase 2provided by RGD
    Primary source
    RGD:1305612
    See related
    EnsemblRapid:ENSRNOG00000019819 AllianceGenome:RGD:1305612
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dus2l; RGD1305612
    Summary
    Predicted to enable several functions, including double-stranded RNA binding activity; nucleotide binding activity; and tRNA-dihydrouridine20 synthase activity. Predicted to be involved in antiviral innate immune response and tRNA dihydrouridine synthesis. Predicted to be located in cytosol and mitochondrion. Predicted to be active in cytoplasm. Orthologous to human DUS2 (dihydrouridine synthase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 53.6), Adrenal (RPKM 38.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dus2 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (50816306..50864559)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (33906517..33954922)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (37990374..38033590)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene dipeptidase 3 Neighboring gene dipeptidase 2 Neighboring gene DEAD-box helicase 28 Neighboring gene nuclear factor of activated T-cells 3 Neighboring gene epithelial splicing regulatory protein 2 Neighboring gene phospholipase A2, group XV

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. An extended dsRBD is required for post-transcriptional modification in human tRNAs. Bou-Nader C, et al. Nucleic Acids Res, 2015 Oct 30. PMID 26429968, Free PMC Article
    2. Interaction of human tRNA-dihydrouridine synthase-2 with interferon-induced protein kinase PKR. Mittelstadt M, et al. Nucleic Acids Res, 2008 Feb. PMID 18096616, Free PMC Article
    3. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables FMN binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADPH binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA dihydrouridine synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA-dihydrouridine20 synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in antiviral innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA dihydrouridine synthesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
    NP_001099651.1
    XP_017456720.1
    XP_017456721.1
    XP_038953546.1
    XP_038953547.2
    XP_038953548.1
    XP_038953550.1
    XP_038953551.1
    XP_063133996.1
    XP_063133997.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106181.1 → NP_001099651.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like

      See identical proteins and their annotated locations for NP_001099651.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473972
      UniProtKB/TrEMBL
      A0A8I5ZYR8, A6IYV4, B0BN89, F7FLX6
      Related
      ENSRNOP00000107611.1, ENSRNOT00000128652.1
      Conserved Domains (2) summary
      cd02801
      Location:13 → 252
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
      cd19871
      Location:369 → 436
      DSRM_DUS2L; double-stranded RNA binding motif of tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (DUS2L) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      50816306..50864559
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097618.2 → XP_038953546.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZYR8, A6IYV4, B0BN89, F7FLX6
      Related
      ENSRNOP00000026827.6, ENSRNOT00000026827.7
      Conserved Domains (2) summary
      cd02801
      Location:13 → 252
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
      cd19871
      Location:369 → 436
      DSRM_DUS2L; double-stranded RNA binding motif of tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (DUS2L) and similar proteins

    2. XM_017601232.3 → XP_017456721.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZYR8

    3. XM_017601231.3 → XP_017456720.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZYR8, A6IYV4, B0BN89, F7FLX6
      Conserved Domains (2) summary
      cd02801
      Location:13 → 252
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
      cd19871
      Location:369 → 436
      DSRM_DUS2L; double-stranded RNA binding motif of tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (DUS2L) and similar proteins

    4. XM_039097620.2 → XP_038953548.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X3

      UniProtKB/TrEMBL
      A6IYV5
      Conserved Domains (2) summary
      cd02801
      Location:1 → 139
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
      cd19871
      Location:256 → 323
      DSRM_DUS2L; double-stranded RNA binding motif of tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (DUS2L) and similar proteins

    5. XM_039097622.2 → XP_038953550.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X4

      Conserved Domains (2) summary
      cd19871
      Location:213 → 280
      DSRM_DUS2L; double-stranded RNA binding motif of tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (DUS2L) and similar proteins
      cl21457
      Location:29 → 96
      TIM; TIM-like beta/alpha barrel domains

    6. XM_063277926.1 → XP_063133996.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X4

    7. XM_039097623.2 → XP_038953551.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X4

      Conserved Domains (2) summary
      cd19871
      Location:213 → 280
      DSRM_DUS2L; double-stranded RNA binding motif of tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (DUS2L) and similar proteins
      cl21457
      Location:29 → 96
      TIM; TIM-like beta/alpha barrel domains

    8. XM_039097619.2 → XP_038953547.2  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X3

      UniProtKB/TrEMBL
      A6IYV5

    9. XM_063277927.1 → XP_063133997.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

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