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    Crcp CGRP receptor component [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114205, updated on 9-Dec-2024

    Summary

    Official Symbol
    Crcpprovided by RGD
    Official Full Name
    CGRP receptor componentprovided by RGD
    Primary source
    RGD:620753
    See related
    EnsemblRapid:ENSRNOG00000071267 AllianceGenome:RGD:620753
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cgrp-rcp
    Summary
    Predicted to enable DNA-directed 5'-3' RNA polymerase activity and calcitonin gene-related peptide receptor activity. Predicted to be involved in transcription initiation at RNA polymerase III promoter. Predicted to act upstream of or within neuropeptide signaling pathway. Located in axon; dendrite; and neuronal cell body. Biomarker of sciatic neuropathy. Orthologous to human CRCP (CGRP receptor component). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 115.6), Spleen (RPKM 102.3) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Crcp in Genome Data Viewer
    Location:
    12q12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (32260108..32315116, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (26623968..26659756, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (30125237..30160857, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene potassium channel tetramerization domain containing 7 Neighboring gene tyrosylprotein sulfotransferase 1 Neighboring gene argininosuccinate lyase Neighboring gene small nucleolar RNA SNORA17 Neighboring gene transfer RNA threonine (anticodon AGU) 12

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-directed 5'-3' RNA polymerase activity  
    enables DNA-directed 5'-3' RNA polymerase activity  
    enables calcitonin gene-related peptide receptor activity  
    enables nucleotide binding  
    enables quinone binding  
    enables vitamin-K-epoxide reductase (warfarin-sensitive) activity  
    Component Evidence Code Pubs
    part_of DNA polymerase III complex  
    part_of DNA polymerase III complex  
    part_of RNA polymerase III complex  
    part_of RNA polymerase III complex  
    part_of RNA polymerase III complex  
    located_in acrosomal vesicle  
    located_in axon PubMed 
    located_in dendrite PubMed 
    located_in endoplasmic reticulum membrane  
    located_in neuronal cell body PubMed 
    located_in plasma membrane  

    General protein information

    Preferred Names
    DNA-directed RNA polymerase III subunit RPC9
    Names
    CGRP-receptor component protein
    CGRPRCP
    RNA polymerase III subunit C9
    calcitonin gene-related peptide-receptor component protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053670.3NP_446122.1  DNA-directed RNA polymerase III subunit RPC9

      See identical proteins and their annotated locations for NP_446122.1

      Status: PROVISIONAL

      Source sequence(s)
      AF440799
      UniProtKB/Swiss-Prot
      Q8VHM6, Q9Z0W9
      UniProtKB/TrEMBL
      A0A8I5XVS4, A6J0N3
      Related
      ENSRNOP00000098382.1, ENSRNOT00000120757.2
      Conserved Domains (1) summary
      smart00657
      Location:1126
      RPOL4c; DNA-directed RNA-polymerase II subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      32260108..32315116 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270985.1XP_063127055.1  DNA-directed RNA polymerase III subunit RPC9 isoform X1

      UniProtKB/TrEMBL
      A0A8I5XVS4, F8WFG9
      Related
      ENSRNOP00000101135.1, ENSRNOT00000136822.1
    2. XM_039089011.1XP_038944939.1  DNA-directed RNA polymerase III subunit RPC9 isoform X2

      Conserved Domains (1) summary
      cl00638
      Location:154
      RNA_pol_Rpb4; RNA polymerase Rpb4
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