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    Trim54 tripartite motif-containing 54 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362708, updated on 9-Dec-2024

    Summary

    Official Symbol
    Trim54provided by RGD
    Official Full Name
    tripartite motif-containing 54provided by RGD
    Primary source
    RGD:1306453
    See related
    EnsemblRapid:ENSRNOG00000006146 AllianceGenome:RGD:1306453
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rnf30
    Summary
    Predicted to enable microtubule binding activity and ubiquitin protein ligase activity. Predicted to be involved in innate immune response. Predicted to act upstream of or within negative regulation of microtubule depolymerization. Predicted to be located in Z disc and microtubule. Predicted to be part of microtubule associated complex. Predicted to be active in cytoplasm. Orthologous to human TRIM54 (tripartite motif containing 54). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 771.4) and Heart (RPKM 513.7) See more
    Orthologs
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    Genomic context

    See Trim54 in Genome Data Viewer
    Location:
    6q14
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (30959306..30978475, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (25239340..25258511, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (26603364..26623950, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene mitochondrial inner membrane protein MPV17 Neighboring gene urocortin Neighboring gene DnaJ heat shock protein family (Hsp40) member C5 gamma Neighboring gene solute carrier family 30 member 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables microtubule binding  
    enables ubiquitin protein ligase activity  
    enables zinc ion binding  
    Component Evidence Code Pubs
    located_in Z disc  
    is_active_in cytoplasm  
    located_in microtubule  
    part_of microtubule associated complex  

    General protein information

    Preferred Names
    tripartite motif-containing protein 54
    Names
    ring finger protein 30

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013217.1NP_001013235.1  tripartite motif-containing protein 54

      See identical proteins and their annotated locations for NP_001013235.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083706
      UniProtKB/Swiss-Prot
      Q5XIH6
      UniProtKB/TrEMBL
      A0A8I5Y850, A6HA76
      Related
      ENSRNOP00000008113.5, ENSRNOT00000008113.8
      Conserved Domains (3) summary
      cd00162
      Location:2685
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam00643
      Location:125163
      zf-B_box; B-box zinc finger
      cl23765
      Location:170273
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      30959306..30978475 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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