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    Morc3 MORC family CW-type zinc finger 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304074, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Morc3provided by RGD
    Official Full Name
    MORC family CW-type zinc finger 3provided by RGD
    Primary source
    RGD:1307924
    See related
    EnsemblRapid:ENSRNOG00000026236 AllianceGenome:RGD:1307924
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zcwcc3
    Summary
    Predicted to enable DNA binding activity; methylated histone binding activity; and protein-macromolecule adaptor activity. Predicted to be involved in antiviral innate immune response; negative regulation of interferon-beta production; and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including peptidyl-serine phosphorylation; positive regulation of cellular senescence; and protein stabilization. Predicted to be located in chromatin and nucleoplasm. Predicted to be active in PML body. Orthologous to human MORC3 (MORC family CW-type zinc finger 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 269.2), Spleen (RPKM 247.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Morc3 in Genome Data Viewer
    Location:
    11q11
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (46621575..46664315)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (33151906..33194650)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (34051928..34094697)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene DOP1 leucine zipper like protein B Neighboring gene interferon induced transmembrane protein3, pseudogene 2 Neighboring gene chromatin assembly factor 1 subunit B Neighboring gene claudin 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Dynamic regulation of p53 subnuclear localization and senescence by MORC3. Takahashi K, et al. Mol Biol Cell, 2007 May. PMID 17332504, Free PMC Article
    2. Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics. Yang W, et al. J Proteome Res, 2012 Feb 3. PMID 22082260, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in antiviral innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within maintenance of protein location in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interferon-beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of cellular senescence ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within post-embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in PML body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in PML body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    MORC family CW-type zinc finger protein 3
    Names
    microrchidia 3
    zinc finger, CW-type with coiled-coil domain 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395628.1 → NP_001382557.1  MORC family CW-type zinc finger protein 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A0A096MIX0
      Conserved Domains (4) summary
      TIGR00606
      Location:697 → 872
      rad50
      cd16931
      Location:18 → 135
      HATPase_MORC-like; Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains
      pfam07496
      Location:409 → 446
      zf-CW; CW-type Zinc Finger
      pfam17942
      Location:249 → 382
      Morc6_S5; Morc6 ribosomal protein S5 domain 2-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      46621575..46664315
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270588.1 → XP_063126658.1  MORC family CW-type zinc finger protein 3 isoform X5

    2. XM_063270584.1 → XP_063126654.1  MORC family CW-type zinc finger protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A096MIX0
      Related
      ENSRNOP00000067908.3, ENSRNOT00000076473.4

    3. XM_063270586.1 → XP_063126656.1  MORC family CW-type zinc finger protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A096MIX0

    4. XM_063270585.1 → XP_063126655.1  MORC family CW-type zinc finger protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A096MIX0

    5. XM_039088413.2 → XP_038944341.1  MORC family CW-type zinc finger protein 3 isoform X3

      UniProtKB/TrEMBL
      A6KPZ0
      Conserved Domains (3) summary
      TIGR00606
      Location:509 → 684
      rad50
      pfam07496
      Location:221 → 258
      zf-CW; CW-type Zinc Finger
      pfam17942
      Location:61 → 194
      Morc6_S5; Morc6 ribosomal protein S5 domain 2-like

    6. XM_039088414.2 → XP_038944342.1  MORC family CW-type zinc finger protein 3 isoform X3

      UniProtKB/TrEMBL
      A6KPZ0
      Conserved Domains (3) summary
      TIGR00606
      Location:509 → 684
      rad50
      pfam07496
      Location:221 → 258
      zf-CW; CW-type Zinc Finger
      pfam17942
      Location:61 → 194
      Morc6_S5; Morc6 ribosomal protein S5 domain 2-like

    7. XM_039088415.2 → XP_038944343.1  MORC family CW-type zinc finger protein 3 isoform X4

      UniProtKB/TrEMBL
      A6KPZ0
      Conserved Domains (3) summary
      TIGR00606
      Location:434 → 609
      rad50
      pfam07496
      Location:146 → 183
      zf-CW; CW-type Zinc Finger
      pfam17942
      Location:1 → 119
      Morc6_S5; Morc6 ribosomal protein S5 domain 2-like

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107109.1: Suppressed sequence

      Description
      NM_001107109.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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