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    Mcm8 minichromosome maintenance 8 homologous recombination repair factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296178, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mcm8provided by RGD
    Official Full Name
    minichromosome maintenance 8 homologous recombination repair factorprovided by RGD
    Primary source
    RGD:1305218
    See related
    EnsemblRapid:ENSRNOG00000021272 AllianceGenome:RGD:1305218
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including chromatin binding activity; mismatch repair complex binding activity; and single-stranded DNA binding activity. Predicted to contribute to single-stranded DNA helicase activity. Predicted to be involved in several processes, including DNA duplex unwinding; protein stabilization; and recombinational repair. Predicted to be located in chromosome. Predicted to be part of MCM8-MCM9 complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 10. Orthologous to human MCM8 (minichromosome maintenance 8 homologous recombination repair factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 34.7), Thymus (RPKM 27.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mcm8 in Genome Data Viewer
    Location:
    3q36
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (140539590..140569891)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (120086741..120117008)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (125470499..125500795)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene chromogranin B Neighboring gene tRNA methyltransferase 6 non-catalytic subunit Neighboring gene cardiolipin synthase 1 Neighboring gene leucine rich repeat neuronal 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MCM8- and MCM9-deficient mice reveal gametogenesis defects and genome instability due to impaired homologous recombination. Lutzmann M, et al. Mol Cell, 2012 Aug 24. PMID 22771120
    2. Mcm8 and Mcm9 form a complex that functions in homologous recombination repair induced by DNA interstrand crosslinks. Nishimura K, et al. Mol Cell, 2012 Aug 24. PMID 22771115
    3. The MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination. Park J, et al. Mol Cell Biol, 2013 Apr. PMID 23401855, Free PMC Article
    4. MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex. Lee KY, et al. Nat Commun, 2015 Jul 28. PMID 26215093, Free PMC Article
    5. MCM9 Is Required for Mammalian DNA Mismatch Repair. Traver S, et al. Mol Cell, 2015 Sep 3. PMID 26300262

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MutLbeta complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables MutSalpha complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables MutSbeta complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables forked DNA-dependent helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables four-way junction helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded 3'-5' DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to single-stranded DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA duplex unwinding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT involved_in DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair via homologous recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in female gamete generation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in female gamete generation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in male gamete generation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in male gamete generation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein localization to chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in recombinational interstrand cross-link repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of MCM complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MCM8-MCM9 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MCM8-MCM9 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA helicase MCM8
    Names
    DNA replication licensing factor MCM8
    minichromosome maintenance complex component 8
    minichromosome maintenance deficient 8
    NP_001099984.1
    XP_006235136.1
    XP_038960517.1
    XP_038960518.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106514.1 → NP_001099984.1  DNA helicase MCM8 isoform a

      See identical proteins and their annotated locations for NP_001099984.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473949
      UniProtKB/Swiss-Prot
      D3ZVK1
      UniProtKB/TrEMBL
      A0A8I5XV71
      Related
      ENSRNOP00000028898.5, ENSRNOT00000028898.7
      Conserved Domains (3) summary
      cd00009
      Location:425 → 583
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      COG1241
      Location:129 → 827
      Mcm2; DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair]
      pfam14551
      Location:88 → 213
      MCM_N; MCM N-terminal domain

    2. NM_001431517.1 → NP_001418446.1  DNA helicase MCM8 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      D3ZVK1
      UniProtKB/TrEMBL
      A0A8I5XV71

    3. NM_001431518.1 → NP_001418447.1  DNA helicase MCM8 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5XV71

    RNA

    1. NR_197230.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      140539590..140569891
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104589.2 → XP_038960517.1  DNA helicase MCM8 isoform X2

      Conserved Domains (2) summary
      COG1241
      Location:129 → 811
      Mcm2; DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair]
      cd17759
      Location:379 → 721
      MCM8; DNA helicase Mcm8

    2. XM_006235074.5 → XP_006235136.1  DNA helicase MCM8 isoform X1

      Conserved Domains (3) summary
      cd00009
      Location:425 → 583
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      COG1241
      Location:129 → 827
      Mcm2; DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair]
      pfam14551
      Location:88 → 213
      MCM_N; MCM N-terminal domain

    3. XM_039104590.2 → XP_038960518.1  DNA helicase MCM8 isoform X3

      Conserved Domains (2) summary
      cd17759
      Location:109 → 451
      MCM8; DNA helicase Mcm8
      pfam17207
      Location:8 → 41
      MCM_OB; MCM OB domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZVK1.1 GenPept UniProtKB/Swiss-Prot:D3ZVK1

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