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    Usp33 ubiquitin specific peptidase 33 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310960, updated on 9-Dec-2024

    Summary

    Official Symbol
    Usp33provided by RGD
    Official Full Name
    ubiquitin specific peptidase 33provided by RGD
    Primary source
    RGD:1307848
    See related
    EnsemblRapid:ENSRNOG00000011294 AllianceGenome:RGD:1307848
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including cysteine-type peptidase activity; small GTPase binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including centrosome duplication; protein deubiquitination; and protein stabilization. Predicted to be located in several cellular components, including centrosome; focal adhesion; and neuronal cell body. Orthologous to human USP33 (ubiquitin specific peptidase 33). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 271.8), Brain (RPKM 265.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Usp33 in Genome Data Viewer
    Location:
    2q45
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (243938958..243988424)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (241283209..241328479)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (257567179..257602817)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 256, pseudogene 2 Neighboring gene nexilin (F actin binding protein) Neighboring gene uncharacterized LOC120100974 Neighboring gene mitoguardin 1 Neighboring gene zinc finger, ZZ-type containing 3 Neighboring gene uncharacterized LOC134485695 Neighboring gene adenylate kinase 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding  
    enables cysteine-type deubiquitinase activity  
    enables cysteine-type endopeptidase activity  
    enables small GTPase binding  
    NOT enables ubiquitin binding  
    enables zinc ion binding  
    Process Evidence Code Pubs
    involved_in axon guidance  
    involved_in cell migration  
    involved_in cellular response to starvation  
    involved_in centrosome duplication  
    involved_in endocytosis  
    involved_in nervous system development  
    involved_in protein K48-linked deubiquitination  
    involved_in protein K63-linked deubiquitination  
    involved_in protein deubiquitination  
    involved_in protein stabilization  
    involved_in proteolysis  
    involved_in regulation of G protein-coupled receptor signaling pathway  
    involved_in regulation of G protein-coupled receptor signaling pathway  
    involved_in regulation of autophagy  
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi apparatus  
    located_in centrosome  
    located_in focal adhesion  
    located_in focal adhesion  
    located_in neuronal cell body  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in perinuclear region of cytoplasm  

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 33
    Names
    ubiquitin specific protease 33
    NP_001401992.1
    XP_038958425.1
    XP_038958426.1
    XP_063138059.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415063.1NP_001401992.1  ubiquitin carboxyl-terminal hydrolase 33

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6AEH4, F1LPJ7
      Related
      ENSRNOP00000060372.3, ENSRNOT00000066125.5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      243938958..243988424
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281989.1XP_063138059.1  ubiquitin carboxyl-terminal hydrolase 33 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AEH4, F1LPJ7
    2. XM_039102497.2XP_038958425.1  ubiquitin carboxyl-terminal hydrolase 33 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AEH4
      Conserved Domains (4) summary
      smart00695
      Location:799883
      DUSP; Domain in ubiquitin-specific proteases
      pfam00443
      Location:153671
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:3089
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      cl12116
      Location:693762
      DUSP; DUSP domain
    3. XM_039102498.2XP_038958426.1  ubiquitin carboxyl-terminal hydrolase 33 isoform X3

      UniProtKB/TrEMBL
      A6HWL4
      Conserved Domains (3) summary
      pfam00443
      Location:153679
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:3089
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      cl12116
      Location:701770
      DUSP; DUSP domain

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