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    Traf3ip3 TRAF3 interacting protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360900, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Traf3ip3provided by RGD
    Official Full Name
    TRAF3 interacting protein 3provided by RGD
    Primary source
    RGD:1304848
    See related
    EnsemblRapid:ENSRNOG00000005565 AllianceGenome:RGD:1304848
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1304848
    Summary
    Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in cytoplasmic pattern recognition receptor signaling pathway and positive regulation of type I interferon production. Predicted to act upstream of or within several processes, including antiviral innate immune response; cellular response to cytokine stimulus; and positive regulation of type I interferon production. Predicted to be active in mitochondrion. Orthologous to human TRAF3IP3 (TRAF3 interacting protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 277.9), Thymus (RPKM 258.1) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Traf3ip3 in Genome Data Viewer
    Location:
    13q27
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (107223499..107248358, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (104694802..104719655, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (111892744..111917368, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene UTP25 small subunit processome component Neighboring gene uncharacterized LOC120096360 Neighboring gene interferon regulatory factor 6 Neighboring gene similar to human chromosome 1 open reading frame 74 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene hydroxysteroid 11-beta dehydrogenase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108851

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within antiviral innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cellular response to interferon-alpha ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cellular response to interferon-beta ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoplasmic pattern recognition receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic pattern recognition receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of interferon-alpha production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of interferon-beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of type I interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    TRAF3-interacting JNK-activating modulator

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014132.2 → NP_001014154.1  TRAF3-interacting JNK-activating modulator isoform 1

      See identical proteins and their annotated locations for NP_001014154.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A8I6AKZ2, A6JH23, F7FMH4, Q5FVQ1
      Related
      ENSRNOP00000007649.4, ENSRNOT00000007649.7
      Conserved Domains (1) summary
      TIGR02168
      Location:277 → 439
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. NM_001429806.1 → NP_001416735.1  TRAF3-interacting JNK-activating modulator isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      107223499..107248358 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090944.2 → XP_038946872.1  TRAF3-interacting JNK-activating modulator isoform X1

      Conserved Domains (2) summary
      COG4372
      Location:216 → 438
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      cd21912
      Location:190 → 234
      CC1_T3JAM; first coiled-coil (CC1) domain found in TRAF3-interacting JNK-activating modulator

    2. XM_039090945.1 → XP_038946873.1  TRAF3-interacting JNK-activating modulator isoform X3

      Conserved Domains (1) summary
      COG4372
      Location:1 → 222
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]

    3. XM_008769865.4 → XP_008768087.2  TRAF3-interacting JNK-activating modulator isoform X2

      Conserved Domains (2) summary
      COG4372
      Location:61 → 282
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      cd21912
      Location:35 → 79
      CC1_T3JAM; first coiled-coil (CC1) domain found in TRAF3-interacting JNK-activating modulator
    Nucleotide Protein Strain
    Heading Accession and Version

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