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    Nkd2 NKD inhibitor of WNT signaling pathway 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308068, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nkd2provided by RGD
    Official Full Name
    NKD inhibitor of WNT signaling pathway 2provided by RGD
    Primary source
    RGD:1311459
    See related
    EnsemblRapid:ENSRNOG00000016103 AllianceGenome:RGD:1311459
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including enzyme binding activity; growth factor binding activity; and myosin heavy chain binding activity. Predicted to be involved in several processes, including negative regulation of canonical Wnt signaling pathway; positive regulation of protein localization to plasma membrane; and positive regulation of proteolysis. Predicted to be located in basolateral plasma membrane; exocytic vesicle; and lateral plasma membrane. Predicted to be active in cytoplasm. Orthologous to human NKD2 (NKD inhibitor of WNT signaling pathway 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 46.3), Kidney (RPKM 28.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nkd2 in Genome Data Viewer
    Location:
    1p11
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (31268856..31299390)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (29442898..29470839)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (32054390..32085416)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene bromodomain containing 9 Neighboring gene small nucleolar RNA SNORA21 Neighboring gene thyroid hormone receptor interactor 13 Neighboring gene solute carrier family 12 member 7 Neighboring gene solute carrier family 6 member 19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Up-Regulation of Corticocerebral NKD2 in Lipopolysaccharide-Induced Neuroinflammation. Cui Z, et al. Cell Mol Neurobiol, 2016 Jan. PMID 26084600
    2. Hypoxic Bone Mesenchymal Stem Cell-Derived Exosomes Direct Schwann Cells Proliferation, Migration, and Paracrine to Accelerate Facial Nerve Regeneration via circRNA_Nkd2/miR-214-3p/MED19 Axis. Wang H, et al. Int J Nanomedicine, 2024. PMID 38371458, Free PMC Article
    3. Naked2 acts as a cargo recognition and targeting protein to ensure proper delivery and fusion of TGF-alpha containing exocytic vesicles at the lower lateral membrane of polarized MDCK cells. Li C, et al. Mol Biol Cell, 2007 Aug. PMID 17553928, Free PMC Article
    4. Myristoylated Naked2 escorts transforming growth factor alpha to the basolateral plasma membrane of polarized epithelial cells. Li C, et al. Proc Natl Acad Sci U S A, 2004 Apr 13. PMID 15064403, Free PMC Article
    5. EGF receptor-independent action of TGF-alpha protects Naked2 from AO7-mediated ubiquitylation and proteasomal degradation. Ding W, et al. Proc Natl Acad Sci U S A, 2008 Sep 9. PMID 18757723, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hypoxic Bone Mesenchymal Stem Cell-Derived Exosomes Direct Schwann Cells Proliferation, Migration, and Paracrine to Accelerate Facial Nerve Regeneration via circRNA_Nkd2/miR-214-3p/MED19 Axis.
      Title: Hypoxic Bone Mesenchymal Stem Cell-Derived Exosomes Direct Schwann Cells Proliferation, Migration, and Paracrine to Accelerate Facial Nerve Regeneration via circRNA_Nkd2/miR-214-3p/MED19 Axis.
    2. NKD2 might be involved in neuronal apoptosis via the Wnt/beta-catenin pathway during neuroinflammation.
      Title: Up-Regulation of Corticocerebral NKD2 in Lipopolysaccharide-Induced Neuroinflammation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables growth factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables myosin heavy chain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi vesicle fusion to target membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell periphery ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in exocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein naked cuticle homolog 2
    Names
    NKD2, WNT signaling pathway inhibitor
    naked cuticle 2 homolog
    naked cuticle homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107454.1 → NP_001100924.1  protein naked cuticle homolog 2

      See identical proteins and their annotated locations for NP_001100924.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474002
      UniProtKB/TrEMBL
      A6JUW2, D4A182
      Related
      ENSRNOP00000021898.5, ENSRNOT00000021898.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      31268856..31299390
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063288362.1 → XP_063144432.1  protein naked cuticle homolog 2 isoform X1

    2. XM_063288366.1 → XP_063144436.1  protein naked cuticle homolog 2 isoform X1

    3. XM_017589090.2 → XP_017444579.1  protein naked cuticle homolog 2 isoform X2

      UniProtKB/TrEMBL
      A6JUW2, D4A182

    4. XM_063288369.1 → XP_063144439.1  protein naked cuticle homolog 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A1L5

    5. XM_063288371.1 → XP_063144441.1  protein naked cuticle homolog 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A619
      Related
      ENSRNOP00000086365.1, ENSRNOT00000118428.2
    Nucleotide Protein Strain
    Heading Accession and Version

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