U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ice2 interactor of little elongation complex ELL subunit 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 691379, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ice2provided by RGD
    Official Full Name
    interactor of little elongation complex ELL subunit 2provided by RGD
    Primary source
    RGD:1585038
    See related
    EnsemblRapid:ENSRNOG00000010160 AllianceGenome:RGD:1585038
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Narg2
    Summary
    Predicted to be involved in positive regulation of transcription by RNA polymerase III; snRNA transcription by RNA polymerase II; and snRNA transcription by RNA polymerase III. Predicted to be located in cytosol; euchromatin; and nuclear body. Predicted to be part of transcription elongation factor complex. Orthologous to human ICE2 (interactor of little elongation complex ELL subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 75.0), Kidney (RPKM 69.9) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Ice2 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (78921962..78965983)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (70043419..70085217)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (75625147..75666959)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480199 Neighboring gene uncharacterized LOC120094342 Neighboring gene RAR-related orphan receptor A Neighboring gene uncharacterized LOC103693133 Neighboring gene annexin A2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. NARG2 encodes a novel nuclear protein with (S/T)PXX motifs that is expressed during development. Sugiura N, et al. Eur J Biochem, 2004 Dec. PMID 15606750
    2. Substance dependence low-density whole genome association study in two distinct American populations. Yu Y, et al. Hum Genet, 2008 Jun. PMID 18438686, Free PMC Article
    3. The little elongation complex functions at initiation and elongation phases of snRNA gene transcription. Hu D, et al. Mol Cell, 2013 Aug 22. PMID 23932780, Free PMC Article
    4. The little elongation complex regulates small nuclear RNA transcription. Smith ER, et al. Mol Cell, 2011 Dec 23. PMID 22195968, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase III ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in snRNA transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snRNA transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in snRNA transcription by RNA polymerase III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snRNA transcription by RNA polymerase III ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Cajal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in euchromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in histone locus body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription elongation factor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    little elongation complex subunit 2
    Names
    NMDA receptor regulated 2
    NMDA receptor-regulated gene 2
    NMDA receptor-regulated protein 2
    interactor of little elongator complex ELL subunit 2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191108.1 → NP_001178037.1  little elongation complex subunit 2

      See identical proteins and their annotated locations for NP_001178037.1

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      D3ZIQ8
      Related
      ENSRNOP00000099306.1, ENSRNOT00000148599.1
      Conserved Domains (1) summary
      pfam10505
      Location:737 → 945
      NARG2_C; NMDA receptor-regulated gene protein 2 C-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      78921962..78965983
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243402.5 → XP_006243464.1  little elongation complex subunit 2 isoform X1

      See identical proteins and their annotated locations for XP_006243464.1

      UniProtKB/TrEMBL
      D3ZIQ8
      Related
      ENSRNOP00000013742.5, ENSRNOT00000013742.9
      Conserved Domains (1) summary
      pfam10505
      Location:737 → 945
      NARG2_C; NMDA receptor-regulated gene protein 2 C-terminus

    2. XM_063266186.1 → XP_063122256.1  little elongation complex subunit 2 isoform X2

    3. XM_017595926.3 → XP_017451415.1  little elongation complex subunit 2 isoform X3

    4. XM_063266187.1 → XP_063122257.1  little elongation complex subunit 2 isoform X4

    5. XM_063266188.1 → XP_063122258.1  little elongation complex subunit 2 isoform X5

    6. XM_063266189.1 → XP_063122259.1  little elongation complex subunit 2 isoform X6

    RNA

    1. XR_001839240.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous