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    Thrb thyroid hormone receptor beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24831, updated on 9-Dec-2024

    Summary

    Official Symbol
    Thrbprovided by RGD
    Official Full Name
    thyroid hormone receptor betaprovided by RGD
    Primary source
    RGD:3858
    See related
    EnsemblRapid:ENSRNOG00000006649 AllianceGenome:RGD:3858
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ERBA2; Nr1a2; T3rec; TRbeta; RATT3REC; c-erbA-2; C-erba-beta
    Summary
    Enables double-stranded DNA binding activity; identical protein binding activity; and nuclear receptor activity. Involved in several processes, including positive regulation of chondrocyte differentiation; positive regulation of ossification; and regulation of lipid metabolic process. Predicted to be located in nuclear body. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Used to study breast cancer. Human ortholog(s) of this gene implicated in several diseases, including cervix uteri carcinoma in situ; prostate cancer; renal cell carcinoma; selective pituitary thyroid hormone resistance; and thyroid hormone resistance syndrome. Orthologous to human THRB (thyroid hormone receptor beta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 121.4), Heart (RPKM 107.7) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Thrb in Genome Data Viewer
    Location:
    15p16
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (10115954..10465231, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (7685180..8031920, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (8890578..9239815, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene nuclear receptor subfamily 1, group D, member 2 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase like 7 Neighboring gene uncharacterized LOC120096915 Neighboring gene uncharacterized LOC120096913 Neighboring gene uncharacterized LOC120096912 Neighboring gene eukaryotic translation initiation factor 1, pseudogene 2 Neighboring gene uncharacterized LOC134482082 Neighboring gene uncharacterized LOC134482083 Neighboring gene biorientation of chromosomes in cell division 1, pseudogene 1 Neighboring gene uncharacterized LOC120096914 Neighboring gene uncharacterized LOC108352884 Neighboring gene polypyrimidine tract binding protein 1, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables chromatin DNA binding  
    enables chromatin DNA binding  
    enables chromatin binding  
    enables double-stranded DNA binding PubMed 
    enables enzyme binding  
    enables enzyme binding  
    enables identical protein binding PubMed 
    enables nuclear receptor activity  
    enables nuclear receptor activity PubMed 
    enables nuclear receptor activity  
    enables nuclear receptor activity  
    enables nuclear receptor activity PubMed 
    enables sequence-specific DNA binding  
    enables sequence-specific double-stranded DNA binding  
    enables sequence-specific double-stranded DNA binding  
    enables thyroid hormone binding  
    enables thyroid hormone binding  
    enables thyroid hormone binding  
    enables transcription coactivator binding  
    enables transcription coactivator binding  
    enables zinc ion binding  
    Items 1 - 25 of 42
    Process Evidence Code Pubs
    acts_upstream_of_or_within animal organ morphogenesis  
    involved_in cell differentiation  
    involved_in cellular response to thyroid hormone stimulus  
    involved_in cellular response to thyroid hormone stimulus  
    involved_in embryonic organ development PubMed 
    involved_in female courtship behavior  
    acts_upstream_of_or_within female courtship behavior  
    involved_in intracellular receptor signaling pathway  
    involved_in mRNA transcription by RNA polymerase II  
    involved_in mRNA transcription by RNA polymerase II  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription  
    involved_in negative regulation of female receptivity  
    acts_upstream_of_or_within negative regulation of female receptivity  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II  
    involved_in positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of chondrocyte differentiation PubMed 
    involved_in positive regulation of ossification PubMed 
    involved_in positive regulation of thyroid hormone receptor signaling pathway  
    involved_in positive regulation of thyroid hormone receptor signaling pathway  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of cholesterol metabolic process PubMed 
    involved_in regulation of heart contraction  
    acts_upstream_of_or_within regulation of heart contraction  
    involved_in regulation of lipid metabolic process PubMed 
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II  
    involved_in regulation of triglyceride metabolic process PubMed 
    involved_in retinal cone cell apoptotic process  
    acts_upstream_of_or_within retinal cone cell apoptotic process  
    involved_in retinal cone cell development  
    acts_upstream_of retinal cone cell development  
    involved_in retinoic acid receptor signaling pathway  
    involved_in sensory perception of sound  
    acts_upstream_of_or_within sensory perception of sound  
    involved_in thyroid hormone receptor signaling pathway  
    involved_in type I pneumocyte differentiation  
    acts_upstream_of_or_within type I pneumocyte differentiation  
    Items 1 - 25 of 42
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex  
    part_of RNA polymerase II transcription regulator complex  
    part_of RNA polymerase II transcription regulator complex  
    located_in nuclear body  
    located_in nuclear body  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    thyroid hormone receptor beta
    Names
    TRbeta2Delta
    nuclear receptor subfamily 1 group A member 2
    thyroid hormone receptor beta 3
    thyroid hormone receptor beta2delta
    thyroid hormone receptor, beta (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270854.1NP_001257783.1  thyroid hormone receptor beta isoform 2

      See identical proteins and their annotated locations for NP_001257783.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      P18113, P37826
      UniProtKB/TrEMBL
      A6K040, F1LP32, F1LQ07
      Conserved Domains (2) summary
      cd06935
      Location:216458
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:106192
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
    2. NM_012672.3NP_036804.2  thyroid hormone receptor beta isoform 1

      See identical proteins and their annotated locations for NP_036804.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      D3ZGG0, D7R7X1, Q3HW36
      Conserved Domains (2) summary
      cd06935
      Location:252494
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:106228
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      10115954..10465231 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273969.1XP_063130039.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      P18113, P37826
      UniProtKB/TrEMBL
      A6K040, F1LP32, F1LQ07
    2. XM_063273981.1XP_063130051.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      P18113, P37826
      UniProtKB/TrEMBL
      A6K040, F1LP32, F1LQ07
    3. XM_063273982.1XP_063130052.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      P18113, P37826
      UniProtKB/TrEMBL
      A6K040, F1LP32, F1LQ07
    4. XM_063273979.1XP_063130049.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      P18113, P37826
      UniProtKB/TrEMBL
      A6K040, F1LP32, F1LQ07
    5. XM_063273971.1XP_063130041.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      P18113, P37826
      UniProtKB/TrEMBL
      A6K040, F1LP32, F1LQ07
    6. XM_063273974.1XP_063130044.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      P18113, P37826
      UniProtKB/TrEMBL
      A6K040, F1LP32, F1LQ07
    7. XM_063273975.1XP_063130045.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      P18113, P37826
      UniProtKB/TrEMBL
      A6K040, F1LP32, F1LQ07
    8. XM_063273972.1XP_063130042.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      P18113, P37826
      UniProtKB/TrEMBL
      A6K040, F1LP32, F1LQ07
    9. XM_063273976.1XP_063130046.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      P18113, P37826
      UniProtKB/TrEMBL
      A6K040, F1LP32, F1LQ07
    10. XM_063273978.1XP_063130048.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      P18113, P37826
      UniProtKB/TrEMBL
      A6K040, F1LP32, F1LQ07
    11. XM_063273970.1XP_063130040.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      P18113, P37826
      UniProtKB/TrEMBL
      A6K040, F1LP32, F1LQ07
      Related
      ENSRNOP00000008989.2, ENSRNOT00000008989.8
    12. XM_063273980.1XP_063130050.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      P18113, P37826
      UniProtKB/TrEMBL
      A6K040, F1LP32, F1LQ07
    13. XM_039092997.2XP_038948925.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      P18113, P37826
      UniProtKB/TrEMBL
      A6K040, F1LP32, F1LQ07
      Conserved Domains (2) summary
      cd06935
      Location:216458
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:106192
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
    14. XM_063273984.1XP_063130054.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      P18113, P37826
      UniProtKB/TrEMBL
      A6K040, F1LP32, F1LQ07
      Related
      ENSRNOP00000058119.6, ENSRNOT00000061402.8
    15. XM_039092998.2XP_038948926.1  thyroid hormone receptor beta isoform X2

      Conserved Domains (2) summary
      cd06935
      Location:129371
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:19105
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
    16. XM_063273988.1XP_063130058.1  thyroid hormone receptor beta isoform X2

    17. XM_063273985.1XP_063130055.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      P18113, P37826
      UniProtKB/TrEMBL
      A6K040, F1LP32, F1LQ07
    18. XM_063273989.1XP_063130059.1  thyroid hormone receptor beta isoform X2

    19. XM_063273986.1XP_063130056.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      P18113, P37826
      UniProtKB/TrEMBL
      A6K040, F1LP32, F1LQ07
    20. XM_063273973.1XP_063130043.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      P18113, P37826
      UniProtKB/TrEMBL
      A6K040, F1LP32, F1LQ07
    21. XM_063273983.1XP_063130053.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      P18113, P37826
      UniProtKB/TrEMBL
      A6K040, F1LP32, F1LQ07
    22. XM_063273990.1XP_063130060.1  thyroid hormone receptor beta isoform X4

      UniProtKB/TrEMBL
      D3ZGG0, D7R7X1, Q3HW36
    23. XM_006251709.4XP_006251771.1  thyroid hormone receptor beta isoform X3

      See identical proteins and their annotated locations for XP_006251771.1

      UniProtKB/TrEMBL
      A0A8I5ZV63, A6K042
      Related
      ENSRNOP00000082752.2, ENSRNOT00000114169.2
      Conserved Domains (2) summary
      cd06935
      Location:269511
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:159245
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
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