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    Umod uromodulin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25128, updated on 4-Jan-2025

    Summary

    Official Symbol
    Umodprovided by RGD
    Official Full Name
    uromodulinprovided by RGD
    Primary source
    RGD:3940
    See related
    EnsemblRapid:ENSRNOG00000015557 AllianceGenome:RGD:3940
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    THP
    Summary
    Predicted to enable IgG binding activity. Predicted to be involved in several processes, including defense response to bacterium; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and metanephric nephron tubule development. Predicted to act upstream of or within with a positive effect on protein phosphorylation. Predicted to act upstream of or within several processes, including citric acid secretion; intracellular monoatomic cation homeostasis; and kidney development. Located in apical part of cell and extracellular space. Human ortholog(s) of this gene implicated in familial juvenile hyperuricemic nephropathy. Orthologous to human UMOD (uromodulin). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Restricted expression toward (RPKM 8401.4) See more
    Orthologs
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    Genomic context

    See Umod in Genome Data Viewer
    Location:
    1q35
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (183247676..183261665, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (173816341..173829681, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (189186027..189199939, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene non-histone chromosomal protein HMG-14-like Neighboring gene glycoprotein 2 Neighboring gene protein disulfide isomerase-like, testis expressed Neighboring gene acyl-CoA synthetase medium-chain family member 5 Neighboring gene acyl-CoA synthetase medium-chain family member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables IgG binding  
    enables IgG binding  
    enables calcium ion binding  
    enables protein binding PubMed 
    Items 1 - 25 of 71
    Process Evidence Code Pubs
    acts_upstream_of_or_within ERAD pathway  
    acts_upstream_of RNA splicing  
    involved_in antibacterial innate immune response  
    involved_in antibacterial innate immune response  
    involved_in antibacterial innate immune response  
    acts_upstream_of_or_within apoptotic process  
    acts_upstream_of_or_within apoptotic signaling pathway  
    acts_upstream_of_or_within autophagy  
    acts_upstream_of_or_within calcium ion homeostasis  
    acts_upstream_of_or_within cellular response to stress  
    acts_upstream_of_or_within cellular response to unfolded protein  
    acts_upstream_of chaperone-mediated protein folding  
    acts_upstream_of_or_within chemical homeostasis  
    acts_upstream_of_or_within chloride ion homeostasis  
    acts_upstream_of_or_within citric acid secretion  
    acts_upstream_of_or_within collecting duct development  
    acts_upstream_of_or_within connective tissue replacement  
    involved_in defense response to Gram-negative bacterium  
    acts_upstream_of_or_within defense response to Gram-negative bacterium  
    involved_in defense response to Gram-negative bacterium  
    involved_in defense response to Gram-negative bacterium  
    acts_upstream_of_or_within endoplasmic reticulum organization  
    acts_upstream_of_or_within gene expression  
    acts_upstream_of_or_within glomerular filtration  
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  
    acts_upstream_of_or_within inflammatory response  
    involved_in innate immune response  
    acts_upstream_of_or_within intracellular calcium ion homeostasis  
    acts_upstream_of_or_within intracellular chloride ion homeostasis  
    acts_upstream_of_or_within intracellular phosphate ion homeostasis  
    acts_upstream_of_or_within intracellular sodium ion homeostasis  
    acts_upstream_of_or_within juxtaglomerular apparatus development  
    acts_upstream_of_or_within kidney development  
    involved_in leukocyte cell-cell adhesion  
    involved_in leukocyte cell-cell adhesion  
    acts_upstream_of_or_within lipid metabolic process  
    acts_upstream_of_or_within loop of Henle development  
    involved_in metanephric ascending thin limb development  
    involved_in metanephric distal convoluted tubule development  
    involved_in metanephric thick ascending limb development  
    acts_upstream_of_or_within micturition  
    involved_in monoatomic ion homeostasis  
    acts_upstream_of_or_within multicellular organismal response to stress  
    acts_upstream_of_or_within multicellular organismal-level homeostasis  
    acts_upstream_of_or_within multicellular organismal-level water homeostasis  
    involved_in neutrophil migration  
    involved_in neutrophil migration  
    involved_in neutrophil migration  
    acts_upstream_of_or_within organ or tissue specific immune response  
    acts_upstream_of_or_within peptidyl-threonine phosphorylation  
    acts_upstream_of_or_within phosphate ion homeostasis  
    acts_upstream_of_or_within potassium ion homeostasis  
    acts_upstream_of_or_within protein localization to vacuole  
    acts_upstream_of_or_within_positive_effect protein phosphorylation  
    acts_upstream_of_or_within protein transport into plasma membrane raft  
    acts_upstream_of_or_within regulation of blood pressure  
    acts_upstream_of_or_within regulation of protein transport  
    acts_upstream_of_or_within regulation of urine volume  
    acts_upstream_of_or_within renal sodium ion absorption  
    acts_upstream_of_or_within renal urate salt excretion  
    acts_upstream_of_or_within renal water homeostasis  
    acts_upstream_of_or_within response to endoplasmic reticulum stress  
    acts_upstream_of_or_within response to lipopolysaccharide  
    acts_upstream_of_or_within response to unfolded protein  
    acts_upstream_of_or_within response to water deprivation  
    acts_upstream_of_or_within response to xenobiotic stimulus  
    acts_upstream_of_or_within sodium ion homeostasis  
    acts_upstream_of_or_within tumor necrosis factor-mediated signaling pathway  
    acts_upstream_of_or_within urate transport  
    acts_upstream_of_or_within urea transmembrane transport  
    Items 1 - 25 of 71
    Items 1 - 20 of 24
    Component Evidence Code Pubs
    located_in apical part of cell PubMed 
    is_active_in apical plasma membrane  
    located_in apical plasma membrane  
    located_in apical plasma membrane  
    located_in apical plasma membrane  
    located_in basolateral plasma membrane  
    located_in basolateral plasma membrane  
    located_in basolateral plasma membrane  
    is_active_in cell surface  
    located_in ciliary membrane  
    located_in cilium  
    located_in cilium  
    located_in endoplasmic reticulum  
    located_in extracellular region  
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    located_in extracellular space  
    located_in membrane  
    located_in membrane  
    located_in plasma membrane  
    located_in side of membrane  
    located_in spindle pole  
    located_in spindle pole  
    located_in spindle pole  
    Items 1 - 20 of 24

    General protein information

    Preferred Names
    uromodulin
    Names
    Urmodulin (Tamm-Horsfall protein)
    tamm-Horsfall urinary glycoprotein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017082.2NP_058778.2  uromodulin precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P27590, Q642D6
      Related
      ENSRNOP00000082923.2, ENSRNOT00000096977.2
      Conserved Domains (3) summary
      smart00179
      Location:67108
      EGF_CA; Calcium-binding EGF-like domain
      smart00241
      Location:337586
      ZP; Zona pellucida (ZP) domain
      pfam12947
      Location:120149
      EGF_3; EGF domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      183247676..183261665 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281291.1XP_063137361.1  uromodulin isoform X1

      UniProtKB/Swiss-Prot
      P27590, Q642D6
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