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    Klk1c4 kallikrein 1-related peptidase C4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100361452, updated on 27-Dec-2024

    Summary

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    Symbol
    Klk1c4provided by RGD
    Full Name
    kallikrein 1-related peptidase C4provided by RGD
    Primary source
    RGD:2320113
    See related
    AllianceGenome:RGD:2320113
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in regulation of systemic arterial blood pressure and zymogen activation. Predicted to be active in extracellular space and secretory granule. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Klk1c4 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (103571089..103575208, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (94434574..94438678, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene kallikrein 1-related peptidase C10 Neighboring gene kallikrein related-peptidase 2 like Neighboring gene kallikrein-2-like Neighboring gene kallikrein 1-related peptidase C6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. Lundwall A, et al. Biol Chem, 2006 Jun. PMID 16800724

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of systemic arterial blood pressure IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in zymogen activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glandular kallikrein-10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      103571089..103575208 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063280942.1 → XP_063137012.1  glandular kallikrein-10 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZLG5, Q63274

    2. XM_039100913.2 → XP_038956841.1  glandular kallikrein-10 isoform X1

      UniProtKB/TrEMBL
      Q63274
      Conserved Domains (1) summary
      cd00190
      Location:25 → 257
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein Strain
    Heading Accession and Version

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