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    Tspoap1 TSPO associated protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287609, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tspoap1provided by RGD
    Official Full Name
    TSPO associated protein 1provided by RGD
    Primary source
    RGD:708563
    See related
    EnsemblRapid:ENSRNOG00000007957 AllianceGenome:RGD:708563
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bzrap1; PRAX-1; RIM-BP1
    Summary
    Predicted to enable benzodiazepine receptor binding activity and voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels. Predicted to be involved in regulation of neurotransmitter secretion. Predicted to act upstream of or within calcium ion transmembrane transport and regulation of presynaptic cytosolic calcium ion concentration. Predicted to be located in cytoplasm. Predicted to be active in calyx of Held; glutamatergic synapse; and mitochondrion. Human ortholog(s) of this gene implicated in dystonia 22, adult-onset and dystonia 22, juvenile-onset. Orthologous to human TSPOAP1 (TSPO associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 128.8), Thymus (RPKM 22.9) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tspoap1 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (73053414..73083640)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (72554220..72586402)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (75053956..75079615)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 43 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134480847 Neighboring gene SPT4 homolog, DSIF elongation factor subunit Neighboring gene microRNA 142 Neighboring gene myeloperoxidase Neighboring gene lactoperoxidase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression profile and up-regulation of PRAX-1 mRNA by antidepressant treatment in the rat brain. Chardenot P, et al. Mol Pharmacol, 2002 Dec. PMID 12435798
    2. Cloning and characterization of PRAX-1. A new protein that specifically interacts with the peripheral benzodiazepine receptor. Galiègue S, et al. J Biol Chem, 1999 Jan 29. PMID 9915832
    3. RIM-BPs Mediate Tight Coupling of Action Potentials to Ca(2+)-Triggered Neurotransmitter Release. Acuna C, et al. Neuron, 2015 Sep 23. PMID 26402606
    4. The RIM/NIM family of neuronal C2 domain proteins. Interactions with Rab3 and a new class of Src homology 3 domain proteins. Wang Y, et al. J Biol Chem, 2000 Jun 30. PMID 10748113
    5. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables benzodiazepine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables benzodiazepine receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables benzodiazepine receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables benzodiazepine receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in neuromuscular synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of neurotransmitter secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of neurotransmitter secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neurotransmitter secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of presynaptic cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in calyx of Held IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in calyx of Held ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    peripheral-type benzodiazepine receptor-associated protein 1
    Names
    RIM binding protein 1
    RIMS-binding protein 1
    benzodiazapine receptor (peripheral) associated protein 1
    benzodiazapine receptor associated protein 1
    benzodiazepine receptor (peripheral) associated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419563.1 → NP_001406492.1  peripheral-type benzodiazepine receptor-associated protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q9JIQ9, Q9JIR0
      UniProtKB/TrEMBL
      A0A8I6AW95, A6HHV4
      Related
      ENSRNOP00000097355.1, ENSRNOT00000103171.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      73053414..73083640
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017597680.3 → XP_017453169.1  peripheral-type benzodiazepine receptor-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q9JIQ9, Q9JIR0

    2. XM_017597684.3 → XP_017453173.1  peripheral-type benzodiazepine receptor-associated protein 1 isoform X3

      UniProtKB/Swiss-Prot
      Q9JIQ9, Q9JIR0
      Conserved Domains (9) summary
      cd12012
      Location:1619 → 1680
      SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12013
      Location:1777 → 1836
      SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12014
      Location:653 → 713
      SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd00063
      Location:881 → 943
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:788 → 866
      fn3; Fibronectin type III domain
      pfam08614
      Location:37 → 183
      ATG16; Autophagy protein 16 (ATG16)
      pfam12718
      Location:346 → 503
      Tropomyosin_1; Tropomyosin like
      cl02488
      Location:332 → 518
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl23720
      Location:427 → 519
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    3. XM_017597682.3 → XP_017453171.1  peripheral-type benzodiazepine receptor-associated protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q9JIQ9, Q9JIR0

    4. XM_213427.10 → XP_213427.5  peripheral-type benzodiazepine receptor-associated protein 1 isoform X4

      See identical proteins and their annotated locations for XP_213427.5

      UniProtKB/Swiss-Prot
      Q9JIQ9, Q9JIR0
      UniProtKB/TrEMBL
      A0A8I6AW95, A6HHV4
      Conserved Domains (9) summary
      cd12012
      Location:1619 → 1680
      SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12013
      Location:1759 → 1818
      SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12014
      Location:653 → 713
      SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd00063
      Location:881 → 943
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:788 → 866
      fn3; Fibronectin type III domain
      pfam08614
      Location:37 → 183
      ATG16; Autophagy protein 16 (ATG16)
      pfam12718
      Location:346 → 503
      Tropomyosin_1; Tropomyosin like
      cl02488
      Location:332 → 518
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl23720
      Location:427 → 519
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    5. XM_017597685.3 → XP_017453174.1  peripheral-type benzodiazepine receptor-associated protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZZW2

    6. XM_017597686.3 → XP_017453175.1  peripheral-type benzodiazepine receptor-associated protein 1 isoform X6

      Conserved Domains (6) summary
      cd12012
      Location:1183 → 1244
      SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12013
      Location:1341 → 1400
      SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12014
      Location:217 → 277
      SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd00063
      Location:445 → 507
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:352 → 430
      fn3; Fibronectin type III domain
      cl23720
      Location:2 → 88
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JIR0.2 GenPept UniProtKB/Swiss-Prot:Q9JIR0

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