Hba-a1 hemoglobin alpha, adult chain 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hba-a1provided by RGD
Official Full Name: hemoglobin alpha, adult chain 1provided by RGD
Primary source: RGD:2782
See related: AllianceGenome:RGD:2782
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: HBAM; Hba1; Hba-a2
Summary: Enables G protein-coupled receptor binding activity and amyloid-beta binding activity. Involved in negative regulation of blood pressure. Predicted to be part of haptoglobin-hemoglobin complex and hemoglobin complex. Used to study alpha thalassemia. Biomarker of Alzheimer's disease. Human ortholog(s) of this gene implicated in Heinz body anemia; alpha thalassemia; familial erythrocytosis 7; and hemoglobin H disease. Orthologous to human HBA1 (hemoglobin subunit alpha 1) and HBA2 (hemoglobin subunit alpha 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 191646.5), Lung (RPKM 53321.9) and 1 other tissue See more
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Genomic context

Location:: 10q12

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (15841724..15842580, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (15337265..15338121, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (15602794..15603649, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results report that hemoglobin chains alpha2 nad beta are expressed in mammalian brain neurons and are regulated by a mitochondrial toxin.
Title: Neurons express hemoglobin alpha- and beta-chains in rat and human brains.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH94431 (e-PCR)
- UniSTS:119679

BI278462 (e-PCR)
- UniSTS:244388

BI280228 (e-PCR)
- UniSTS:249026

BI282742 (e-PCR)
- UniSTS:249834

UniSTS:465391 (e-PCR)
- UniSTS:465391

Hba-a1 (e-PCR), detects polymorphism
- UniSTS:465391

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables amyloid-beta binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to haptoglobin binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxygen binding	IBA Inferred from Biological aspect of Ancestor more info
enables oxygen carrier activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in carbon dioxide transport	NAS Non-traceable Author Statement more info	PubMed
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within erythrocyte development	ISO Inferred from Sequence Orthology more info
involved_in hydrogen peroxide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood pressure	IDA Inferred from Direct Assay more info	PubMed
involved_in nitric oxide transport	ISO Inferred from Sequence Orthology more info
involved_in oxygen transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in response to stilbenoid	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of haptoglobin-hemoglobin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of hemoglobin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of hemoglobin complex	ISO Inferred from Sequence Orthology more info
part_of hemoglobin complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: hemoglobin subunit alpha-1/2

Names: alpha-1/2-globin; hemoglobin alpha 1 chain; hemoglobin alpha, adult chain 2; hemoglobin alpha-1/2 chain; hemoglobin, alpha 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013096.2 → NP_037228.1 hemoglobin subunit alpha-1/2

See identical proteins and their annotated locations for NP_037228.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

P01946, P33583, Q63243, Q80XV2, Q91V15

UniProtKB/TrEMBL

A0A1K0FUB4, B1H216

Conserved Domains (1) summary

cd08927
Location:3 → 142

Hb-alpha_like; Hemoglobin alpha, zeta, mu, theta, and related Hb subunits