Abcc6 ATP binding cassette subfamily C member 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Abcc6provided by RGD
Official Full Name: ATP binding cassette subfamily C member 6provided by RGD
Primary source: RGD:620268
See related: EnsemblRapid:ENSRNOG00000028781 AllianceGenome:RGD:620268
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mrp6
Summary: Enables several functions, including ATP binding activity; ATP hydrolysis activity; and inorganic diphosphate transmembrane transporter activity. Involved in several processes, including inorganic diphosphate transport; intracellular phosphate ion homeostasis; and xenobiotic transmembrane transport. Located in apical plasma membrane; basolateral plasma membrane; and lateral plasma membrane. Used to study pseudoxanthoma elasticum. Human ortholog(s) of this gene implicated in arterial calcification of infancy; coronary artery disease; and pseudoxanthoma elasticum. Orthologous to human ABCC6 (ATP binding cassette subfamily C member 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 322.1) and Kidney (RPKM 51.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (105583681..105637895, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (96447224..96501464, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (101954786..102013252, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study suggests a critical role of hepatic ABCC6 in contributing to plasma inorganic pyrophosphate levels, identifying liver as a target of molecular correction to counteract ectopic mineralization in pseudoxanthoma elasticum
Title: Abcc6 Knockout Rat Model Highlights the Role of Liver in PPi Homeostasis in Pseudoxanthoma Elasticum.
In a rat model of CKD, ABCC6 protein expression was decreased in liver and kidney, however mRNA levels were unchanged.
Title: Chronic kidney disease results in deficiency of ABCC6, the novel inhibitor of vascular calcification.
In the absence of transfected rat ABCC6, HeLa and HEK293 cells released almost no ATP, but on induction of rat ABCC6, they released substantial amounts of ATP into the cell culture medium.
Title: ABCC6-mediated ATP secretion by the liver is the main source of the mineralization inhibitor inorganic pyrophosphate in the systemic circulation-brief report.

Submit: New GeneRIF Correction

General gene information

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Markers

RH134844 (e-PCR)
- UniSTS:218122

D1Got95 (e-PCR)
- UniSTS:111869

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ABC-type glutathione S-conjugate transporter activity	ISO Inferred from Sequence Orthology more info
enables ABC-type glutathione S-conjugate transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables ABC-type xenobiotic transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP hydrolysis activity	IDA Inferred from Direct Assay more info	PubMed
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase-coupled transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables inorganic diphosphate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in ATP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in ATP transport	IDA Inferred from Direct Assay more info	PubMed
involved_in ATP transport	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
involved_in inhibition of non-skeletal tissue mineralization	ISO Inferred from Sequence Orthology more info
involved_in inorganic diphosphate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in inorganic diphosphate transport	ISO Inferred from Sequence Orthology more info
involved_in intracellular phosphate ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular phosphate ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in leukotriene transport	ISO Inferred from Sequence Orthology more info
involved_in leukotriene transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphate ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in response to magnesium ion	ISO Inferred from Sequence Orthology more info
involved_in response to sodium phosphate	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in xenobiotic transmembrane transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ATP-binding cassette sub-family C member 6

Names: ATP-binding cassette, sub-family C (CFTR/MRP), member 6; ATP-binding cassette, subfamily C (CFTR/MRP), member 6; MLP-1; MRP-like protein 1; liver multidrug resistance-associated protein 6; multidrug resistance-associated protein 6

NP_112275.1

EC 7.6.2.3

XP_017445259.1

EC 7.6.2.3

XP_038948021.1

EC 7.6.2.3

XP_038948028.1

EC 7.6.2.3

XP_038948044.1

EC 7.6.2.3

XP_063131205.1

EC 7.6.2.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031013.1 → NP_112275.1 ATP-binding cassette sub-family C member 6

See identical proteins and their annotated locations for NP_112275.1

Status: PROVISIONAL

Source sequence(s)

U73038

UniProtKB/Swiss-Prot

O88269

UniProtKB/TrEMBL

A6JBA8

Related

ENSRNOP00000051412.1, ENSRNOT00000042115.3

Conserved Domains (4) summary

TIGR00957
Location:36 → 1501

MRP_assoc_pro; multi drug resistance-associated protein (MRP)

cd03244
Location:1262 → 1482

ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein

cd03250
Location:627 → 828

ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C

cl00549
Location:950 → 1215

ABC_membrane; ABC transporter transmembrane region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

105583681..105637895 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039092100.2 → XP_038948028.1 ATP-binding cassette sub-family C member 6 isoform X2

UniProtKB/TrEMBL

A6JBA8

Conserved Domains (1) summary

TIGR00957
Location:4 → 1398

MRP_assoc_pro; multi drug resistance-associated protein (MRP)
XM_039092093.2 → XP_038948021.1 ATP-binding cassette sub-family C member 6 isoform X1

UniProtKB/TrEMBL

A6JBA8

Conserved Domains (1) summary

TIGR00957
Location:36 → 1414

MRP_assoc_pro; multi drug resistance-associated protein (MRP)
XM_063275135.1 → XP_063131205.1 ATP-binding cassette sub-family C member 6 isoform X3

UniProtKB/TrEMBL

A6JBA8
XM_017589770.3 → XP_017445259.1 ATP-binding cassette sub-family C member 6 isoform X3

UniProtKB/TrEMBL

A6JBA8
XM_039092116.2 → XP_038948044.1 ATP-binding cassette sub-family C member 6 isoform X4

Conserved Domains (1) summary

TIGR00957
Location:25 → 894

MRP_assoc_pro; multi drug resistance-associated protein (MRP)