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    Necap1 NECAP endocytosis associated 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312694, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Necap1provided by RGD
    Official Full Name
    NECAP endocytosis associated 1provided by RGD
    Primary source
    RGD:1306053
    See related
    EnsemblRapid:ENSRNOG00000009236 AllianceGenome:RGD:1306053
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306053
    Summary
    Involved in presynaptic endocytosis. Is active in presynapse. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 21. Orthologous to human NECAP1 (NECAP endocytosis associated 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 482.0), Kidney (RPKM 171.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Necap1 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (157775890..157790992)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (156103935..156119068)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (155709712..155724801)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene complement C3a receptor 1 Neighboring gene ribosomal protein L31, pseudogene 10 Neighboring gene ribosomal protein L7, pseudogene 25 Neighboring gene C-type lectin domain family 4, member A1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of the localization and function of NECAP 1 in neurons. Murshid A, et al. J Neurochem, 2006 Sep. PMID 16879712
    2. Dual engagement regulation of protein interactions with the AP-2 adaptor alpha appendage. Mishra SK, et al. J Biol Chem, 2004 Oct 29. PMID 15292237
    3. NECAP 1 regulates AP-2 interactions to control vesicle size, number, and cargo during clathrin-mediated endocytosis. Ritter B, et al. PLoS Biol, 2013 Oct. PMID 24130457, Free PMC Article
    4. Identification of a family of endocytic proteins that define a new alpha-adaptin ear-binding motif. Ritter B, et al. EMBO Rep, 2003 Nov. PMID 14555962, Free PMC Article
    5. The NECAP PHear domain increases clathrin accessory protein binding potential. Ritter B, et al. EMBO J, 2007 Sep 19. PMID 17762867, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114570

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in presynaptic endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in presynaptic endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of clathrin vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of clathrin vesicle coat IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of clathrin vesicle coat ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in clathrin-coated pit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adaptin ear-binding coat-associated protein 1
    Names
    NECAP endocytosis-associated protein 1
    NECAP-1
    adaptin ear-binding clathrin-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029919.2 → NP_001025090.1  adaptin ear-binding coat-associated protein 1

      See identical proteins and their annotated locations for NP_001025090.1

      Status: VALIDATED

      Source sequence(s)
      BC097496, CO402572
      UniProtKB/Swiss-Prot
      P69682, Q4QR67
      UniProtKB/TrEMBL
      A0A8L2Q6N8, A6ILG2
      Related
      ENSRNOP00000106742.1, ENSRNOT00000146409.1
      Conserved Domains (1) summary
      pfam07933
      Location:7 → 164
      DUF1681; Protein of unknown function (DUF1681)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      157775890..157790992
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237305.3 → XP_006237367.1  adaptin ear-binding coat-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8L2Q6N8
      Related
      ENSRNOP00000013272.7, ENSRNOT00000013272.8
      Conserved Domains (1) summary
      pfam07933
      Location:11 → 143
      DUF1681; Protein of unknown function (DUF1681)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P69682.1 GenPept UniProtKB/Swiss-Prot:P69682

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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