Slc29a4 solute carrier family 29 member 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc29a4provided by RGD
Official Full Name: solute carrier family 29 member 4provided by RGD
Primary source: RGD:1310545
See related: EnsemblRapid:ENSRNOG00000001115 AllianceGenome:RGD:1310545
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables monoamine transmembrane transporter activity. Involved in monoamine transport. Located in apical plasma membrane and basolateral plasma membrane. Orthologous to human SLC29A4 (solute carrier family 29 member 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 18.5), Adrenal (RPKM 15.2) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12p11

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (16967047..16998276, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (11853540..11884660, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (13914114..13924511, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest the elimination of histamine from the CSF via plasma membrane monoamine transporter at the blood-brain barrier and blood-CSF barrier
Title: Histamine elimination from the cerebrospinal fluid across the blood-cerebrospinal fluid barrier: involvement of plasma membrane monoamine transporter (PMAT/SLC29A4).

Submit: New GeneRIF Correction

General gene information

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Markers

NoName (e-PCR)
- UniSTS:547070

Slc29a4 (e-PCR), detects polymorphism
- UniSTS:547070

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables efflux transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables monoamine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables monoamine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables monoamine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables monoatomic cation transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables neurotransmitter transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables nucleoside transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables organic acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables organic cation transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables toxin transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables xenobiotic transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adenosine transport	ISO Inferred from Sequence Orthology more info
involved_in cellular detoxification	ISO Inferred from Sequence Orthology more info
involved_in dopamine transport	ISO Inferred from Sequence Orthology more info
involved_in dopamine uptake	ISO Inferred from Sequence Orthology more info
involved_in epinephrine transport	ISO Inferred from Sequence Orthology more info
involved_in epinephrine uptake	ISO Inferred from Sequence Orthology more info
involved_in export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in histamine transport	ISO Inferred from Sequence Orthology more info
involved_in histamine uptake	ISO Inferred from Sequence Orthology more info
involved_in monoamine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in monoamine transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter transport	ISO Inferred from Sequence Orthology more info
involved_in norepinephrine transport	ISO Inferred from Sequence Orthology more info
involved_in norepinephrine uptake	ISO Inferred from Sequence Orthology more info
involved_in nucleoside transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in organic acid transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in organic cation transport	ISO Inferred from Sequence Orthology more info
involved_in serotonin transport	ISO Inferred from Sequence Orthology more info
involved_in serotonin uptake	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in presynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: equilibrative nucleoside transporter 4

Names: solute carrier family 29 (equilibrative nucleoside transporter), member 4; solute carrier family 29 (nucleoside transporters), member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105911.1 → NP_001099381.1 equilibrative nucleoside transporter 4

See identical proteins and their annotated locations for NP_001099381.1

Status: PROVISIONAL

Source sequence(s)

CH474012

UniProtKB/TrEMBL

A6K1P5

Conserved Domains (1) summary

cl15430
Location:73 → 495

Nucleoside_tran; Nucleoside transporter

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

16967047..16998276 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039089186.2 → XP_038945114.1 equilibrative nucleoside transporter 4 isoform X1

UniProtKB/TrEMBL

F1M2Y4

Conserved Domains (1) summary

cl15430
Location:73 → 496

Nucleoside_tran; Nucleoside transporter
XM_039089185.2 → XP_038945113.1 equilibrative nucleoside transporter 4 isoform X1

UniProtKB/TrEMBL

F1M2Y4

Related

ENSRNOP00000001477.6, ENSRNOT00000001477.7

Conserved Domains (1) summary

cl15430
Location:73 → 496

Nucleoside_tran; Nucleoside transporter
XM_039089187.2 → XP_038945115.1 equilibrative nucleoside transporter 4 isoform X2

Conserved Domains (1) summary

cl15430
Location:29 → 343

Nucleoside_tran; Nucleoside transporter