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    Dmrta2 DMRT-like family A2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313471, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dmrta2provided by RGD
    Official Full Name
    DMRT-like family A2provided by RGD
    Primary source
    RGD:1308173
    See related
    EnsemblRapid:ENSRNOG00000068045 AllianceGenome:RGD:1308173
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Predicted to be involved in germ cell development; regulation of transcription by RNA polymerase II; and sex differentiation. Predicted to act upstream of or within several processes, including nervous system development; positive regulation of neuroblast proliferation; and stem cell fate specification. Predicted to be active in nucleus. Orthologous to human DMRTA2 (DMRT like family A2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 10.0), Brain (RPKM 3.7) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dmrta2 in Genome Data Viewer
    Location:
    5q35
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (130034473..130040283)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (124805883..124811694)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (129754295..129760045)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene Fas associated factor 1 Neighboring gene doublesex and mab-3 related transcription factor like family A2, opposite strand like Neighboring gene ELAV like RNA binding protein 4 Neighboring gene AGBL carboxypeptidase 4 Neighboring gene BEN domain containing 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Doublesex and mab-3-related transcription factor 5 promotes midbrain dopaminergic identity in pluripotent stem cells by enforcing a ventral-medial progenitor fate. Gennet N, et al. Proc Natl Acad Sci U S A, 2011 May 31. PMID 21576465, Free PMC Article
    2. Vertebrate DM domain proteins bind similar DNA sequences and can heterodimerize on DNA. Murphy MW, et al. BMC Mol Biol, 2007 Jul 2. PMID 17605809, Free PMC Article
    3. The mammalian DM domain transcription factor Dmrta2 is required for early embryonic development of the cerebral cortex. Konno D, et al. PLoS One, 2012. PMID 23056351, Free PMC Article
    4. The doublesex homolog Dmrt5 is required for the development of the caudomedial cerebral cortex in mammals. Saulnier A, et al. Cereb Cortex, 2013 Nov. PMID 22923088, Free PMC Article
    5. Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation. Rajan S, et al. Physiol Genomics, 2012 Feb 1. PMID 22147266

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cerebral cortex regionalization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within dopaminergic neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of neuroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuron fate specification ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of neuroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sex differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within skeletal muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within stem cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within stem cell fate specification ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    doublesex- and mab-3-related transcription factor A2
    Names
    doublesex and mab-3 related transcription factor like family A2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107951.2 → NP_001101421.2  doublesex- and mab-3-related transcription factor A2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I6ANN9
      Related
      ENSRNOP00000094808.1, ENSRNOT00000099147.2
      Conserved Domains (2) summary
      cd14418
      Location:311 → 352
      CUE_DMA_DMRTA2; CUE-like DMA domain found in doublesex- and mab-3-related transcription factor A2 (DMRTA2)
      pfam00751
      Location:65 → 111
      DM; DM DNA binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      130034473..130040283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109960.2 → XP_038965888.1  doublesex- and mab-3-related transcription factor A2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ANN9
      Conserved Domains (2) summary
      cd14418
      Location:311 → 352
      CUE_DMA_DMRTA2; CUE-like DMA domain found in doublesex- and mab-3-related transcription factor A2 (DMRTA2)
      pfam00751
      Location:65 → 111
      DM; DM DNA binding domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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