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    Chtop chromatin target of PRMT1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361990, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Chtopprovided by RGD
    Official Full Name
    chromatin target of PRMT1provided by RGD
    Primary source
    RGD:1359407
    See related
    EnsemblRapid:ENSRNOG00000012760 AllianceGenome:RGD:1359407
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fop; SRAG
    Summary
    Predicted to enable mRNA binding activity and methyl-CpG binding activity. Predicted to be involved in chromatin remodeling; mRNA export from nucleus; and positive regulation of helicase activity. Predicted to act upstream of or within in utero embryonic development. Predicted to be located in nucleolus. Predicted to be part of transcription export complex. Predicted to be active in nuclear speck. Orthologous to human CHTOP (chromatin target of PRMT1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 224.4), Spleen (RPKM 165.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Chtop in Genome Data Viewer
    Location:
    2q34
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (178278848..178291142, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (175981266..175992820, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (189887850..189900079, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene interleukin enhancer binding factor 2 Neighboring gene SNAP-associated protein Neighboring gene S100 calcium binding protein A1 Neighboring gene S100 calcium binding protein A13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Chtop is a component of the dynamic TREX mRNA export complex. Chang CT, et al. EMBO J, 2013 Feb 6. PMID 23299939, Free PMC Article
    2. 5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex. Takai H, et al. Cell Rep, 2014 Oct 9. PMID 25284789
    3. Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice. Wilson R, et al. Wellcome Open Res, 2016. PMID 27996060, Free PMC Article
    4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables methyl-CpG binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methyl-CpG binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ATP-dependent activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription export complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    chromatin target of PRMT1 protein
    Names
    Friend of PRMT1 protein
    small arginine- and glycine-rich protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014175.3 → NP_001014197.1  chromatin target of PRMT1 protein isoform 4

      See identical proteins and their annotated locations for NP_001014197.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6J6N1
      Conserved Domains (1) summary
      pfam13865
      Location:162 → 199
      FoP_duplication; C-terminal duplication domain of Friend of PRMT1

    2. NM_001399723.1 → NP_001386652.1  chromatin target of PRMT1 protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6J6M9, A6J6N2
      Related
      ENSRNOP00000010455.6, ENSRNOT00000010455.10

    3. NM_001399724.1 → NP_001386653.1  chromatin target of PRMT1 protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q498T2, Q66H75
      UniProtKB/TrEMBL
      A6J6N2

    4. NM_001399725.1 → NP_001386654.1  chromatin target of PRMT1 protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6J6M8, A6J6N1
      Related
      ENSRNOP00000017561.5, ENSRNOT00000017561.9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      178278848..178291142 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102689.2 → XP_038958617.1  chromatin target of PRMT1 protein isoform X2

      UniProtKB/TrEMBL
      A6J6N2
      Conserved Domains (1) summary
      pfam13865
      Location:235 → 271
      FoP_duplication; C-terminal duplication domain of Friend of PRMT1

    2. XM_039102691.2 → XP_038958619.1  chromatin target of PRMT1 protein isoform X5

      Conserved Domains (1) summary
      pfam13865
      Location:190 → 226
      FoP_duplication; C-terminal duplication domain of Friend of PRMT1

    3. XM_039102687.2 → XP_038958615.1  chromatin target of PRMT1 protein isoform X1

      UniProtKB/TrEMBL
      A6J6N0, A6J6N2
      Related
      ENSRNOP00000102443.1, ENSRNOT00000137072.1
      Conserved Domains (1) summary
      pfam13865
      Location:236 → 272
      FoP_duplication; C-terminal duplication domain of Friend of PRMT1

    4. XM_063282168.1 → XP_063138238.1  chromatin target of PRMT1 protein isoform X6

      UniProtKB/TrEMBL
      A6J6N1

    5. XM_063282167.1 → XP_063138237.1  chromatin target of PRMT1 protein isoform X4

      UniProtKB/Swiss-Prot
      Q498T2, Q66H75
      UniProtKB/TrEMBL
      A6J6N2

    6. XM_006232710.5 → XP_006232772.1  chromatin target of PRMT1 protein isoform X3

      See identical proteins and their annotated locations for XP_006232772.1

      UniProtKB/TrEMBL
      A6J6M9, A6J6N2
      Conserved Domains (1) summary
      pfam13865
      Location:209 → 246
      FoP_duplication; C-terminal duplication domain of Friend of PRMT1

    7. XM_039102688.2 → XP_038958616.1  chromatin target of PRMT1 protein isoform X1

      UniProtKB/TrEMBL
      A6J6N0, A6J6N2
      Conserved Domains (1) summary
      pfam13865
      Location:236 → 272
      FoP_duplication; C-terminal duplication domain of Friend of PRMT1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q498T2.1 GenPept UniProtKB/Swiss-Prot:Q498T2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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