Fem1c fem-1 homolog C [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fem1cprovided by RGD
Official Full Name: fem-1 homolog Cprovided by RGD
Primary source: RGD:1309322
See related: EnsemblRapid:ENSRNOG00000003578 AllianceGenome:RGD:1309322
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of Cul2-RING ubiquitin ligase complex. Orthologous to human FEM1C (fem-1 homolog C). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 90.0), Testes (RPKM 87.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18q11

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (41419511..41445300, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (39232900..39258692, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (40493156..40518988, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

FEM1C (e-PCR)
- UniSTS:504927

RH139513 (e-PCR)
- UniSTS:221599

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ubiquitin-like ligase-substrate adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Cul2-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein fem-1 homolog C

Names: feminization 1 homolog c; feminization of XX and XO animals 1C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106932.1 → NP_001100402.1 protein fem-1 homolog C

See identical proteins and their annotated locations for NP_001100402.1

Status: PROVISIONAL

Source sequence(s)

CH473971

UniProtKB/TrEMBL

A6IWV6, D3ZZR4

Related

ENSRNOP00000004784.3, ENSRNOT00000004784.8

Conserved Domains (4) summary

PHA02876
Location:164 → 568

PHA02876; ankyrin repeat protein; Provisional

COG0666
Location:462 → 599

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

sd00045
Location:118 → 146

ANK; ANK repeat [structural motif]

pfam12796
Location:87 → 178

Ank_2; Ankyrin repeats (3 copies)