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    Jam2 junctional adhesion molecule 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 619374, updated on 9-Dec-2024

    Summary

    Official Symbol
    Jam2provided by RGD
    Official Full Name
    junctional adhesion molecule 2provided by RGD
    Primary source
    RGD:1561692
    See related
    EnsemblRapid:ENSRNOG00000042848 AllianceGenome:RGD:1561692
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable integrin binding activity. Predicted to be involved in several processes, including hematopoietic stem cell migration to bone marrow; leukocyte tethering or rolling; and negative regulation of myelination. Predicted to act upstream of or within negative regulation of cell adhesion. Predicted to be located in cell-cell contact zone and somatodendritic compartment. Predicted to be part of protein complex involved in cell adhesion. Predicted to be active in cell surface; plasma membrane; and tight junction. Human ortholog(s) of this gene implicated in basal ganglia calcification. Orthologous to human JAM2 (junctional adhesion molecule 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 308.3), Lung (RPKM 301.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Jam2 in Genome Data Viewer
    Location:
    11q11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (37316287..37366517)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (23830820..23880071)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (24235310..24285279)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA70 Neighboring gene mitochondrial ribosomal protein L39 Neighboring gene ATP synthase peripheral stalk subunit F6 Neighboring gene GA binding protein transcription factor subunit alpha Neighboring gene amyloid beta precursor protein Neighboring gene uncharacterized LOC134480962

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    NOT located_in axon  
    is_active_in cell surface  
    located_in cell surface  
    located_in cell-cell contact zone  
    is_active_in plasma membrane  
    located_in plasma membrane  
    part_of protein complex involved in cell adhesion  
    part_of protein complex involved in cell adhesion  
    located_in somatodendritic compartment  
    is_active_in tight junction  
    located_in tight junction  

    General protein information

    Preferred Names
    junctional adhesion molecule B
    Names
    junction adhesion molecule 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034004.1 → NP_001029176.1  junctional adhesion molecule B precursor

      See identical proteins and their annotated locations for NP_001029176.1

      Status: PROVISIONAL

      Source sequence(s)
      BC105305
      UniProtKB/TrEMBL
      A6JL57, F1M065, Q3MHC0
      Related
      ENSRNOP00000049564.6, ENSRNOT00000046973.7
      Conserved Domains (3) summary
      cd00096
      Location:47 → 113
      Ig; Immunoglobulin domain
      smart00408
      Location:148 → 221
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:37 → 131
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      37316287..37366517
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088608.2 → XP_038944536.1  junctional adhesion molecule B isoform X1

      UniProtKB/TrEMBL
      A6JL57
      Conserved Domains (2) summary
      cd00096
      Location:38 → 42
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:36 → 132
      Ig; Immunoglobulin domain
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