Spire1 spire-type actin nucleation factor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Spire1provided by RGD
Official Full Name: spire-type actin nucleation factor 1provided by RGD
Primary source: RGD:1305892
See related: EnsemblRapid:ENSRNOG00000025324 AllianceGenome:RGD:1305892
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including cytoskeleton organization; cytoskeleton-dependent cytokinesis; and positive regulation of mitochondrial fission. Predicted to act upstream of or within behavioral fear response and dendritic spine development. Predicted to be located in several cellular components, including Golgi apparatus; cleavage furrow; and mitochondrial outer membrane. Predicted to be active in cell cortex and cytoplasmic vesicle membrane. Orthologous to human SPIRE1 (spire type actin nucleation factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 215.9), Adrenal (RPKM 109.9) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18q12.1

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (63311800..63441545, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (61041914..61171670, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (63226557..63357420, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Spire 1 is an ES regulator to support germ cell development during spermatogenesis.
Title: Actin nucleator Spire 1 is a regulator of ectoplasmic specialization in the testis.

Submit: New GeneRIF Correction

General gene information

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Markers

RH132324 (e-PCR)
- UniSTS:215607

D18Wox6 (e-PCR)
- UniSTS:118071

RH129559 (e-PCR)
- UniSTS:212861

AW550622 (e-PCR)
- UniSTS:181139

RH129069 (e-PCR)
- UniSTS:212377

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Golgi vesicle transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Golgi vesicle transport	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin filament network formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin nucleation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within behavioral fear response	ISO Inferred from Sequence Orthology more info
involved_in cleavage furrow formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cleavage furrow formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dendritic spine development	ISO Inferred from Sequence Orthology more info
involved_in establishment of meiotic spindle localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of meiotic spindle localization	ISO Inferred from Sequence Orthology more info
involved_in formin-nucleated actin cable assembly	ISO Inferred from Sequence Orthology more info
involved_in intracellular transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular transport	ISO Inferred from Sequence Orthology more info
involved_in polar body extrusion after meiotic divisions	IBA Inferred from Biological aspect of Ancestor more info
involved_in polar body extrusion after meiotic divisions	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of double-strand break repair	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial fission	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cleavage furrow	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasmic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein spire homolog 1

Names: spire homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001415681.1 → NP_001402610.1 protein spire homolog 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000018

UniProtKB/TrEMBL

A0A0G2JZR0, A6IXV4, D3ZEX7

Related

ENSRNOP00000062729.1, ENSRNOT00000066103.4
NM_001415682.1 → NP_001402611.1 protein spire homolog 1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000018

UniProtKB/TrEMBL

A0A8I6B5T2, A6IXV3
NM_001415684.1 → NP_001402613.1 protein spire homolog 1 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000018

UniProtKB/TrEMBL

A6IXV3

Related

ENSRNOP00000097454.2, ENSRNOT00000108704.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

63311800..63441545 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017600946.3 → XP_017456435.1 protein spire homolog 1 isoform X2

UniProtKB/TrEMBL

A6IXV4, D3ZEX7
XM_006254860.5 → XP_006254922.1 protein spire homolog 1 isoform X1

UniProtKB/TrEMBL

A6IXV4, D3ZEX7

Related

ENSRNOP00000071145.3, ENSRNOT00000089408.3

Conserved Domains (2) summary

cd15767
Location:630 → 750

FYVE_SPIR1; FYVE-related domain found in protein spire homolog 1 (Spire1) and similar proteins

pfam16474
Location:24 → 220

KIND; Kinase non-catalytic C-lobe domain
XM_063277313.1 → XP_063133383.1 protein spire homolog 1 isoform X4

UniProtKB/TrEMBL

A6IXV4, D3ZEX7
XM_039096794.2 → XP_038952722.1 protein spire homolog 1 isoform X3

UniProtKB/TrEMBL

A6IXV4, D3ZEX7

Related

ENSRNOP00000096614.2, ENSRNOT00000112905.2

Conserved Domains (6) summary

cd15767
Location:537 → 657

FYVE_SPIR1; FYVE-related domain found in protein spire homolog 1 (Spire1) and similar proteins

cd22065
Location:151 → 182

WH2_Spire_1-2_r1; first tandem Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif) repeat of protein Spire homologs 1 and 2

cd22078
Location:191 → 222

WH2_Spire1_r2-like; second tandem Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif) repeat of protein Spire homolog 1 (Spir1), and related proteins

cd22080
Location:256 → 279

WH2_Spire1_r4; fourth tandem Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif) repeat of protein Spire homolog 1

cl21453
Location:14 → 127

PKc_like; Protein Kinases, catalytic domain

cl41728
Location:225 → 247

WH2; Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif), and similar proteins
XM_063277314.1 → XP_063133384.1 protein spire homolog 1 isoform X5

UniProtKB/TrEMBL

A6IXV4, D3ZEX7

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001107381.1: Suppressed sequence

Description

NM_001107381.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.