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    Oxt oxytocin/neurophysin I prepropeptide [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25504, updated on 9-Dec-2024

    Summary

    Official Symbol
    Oxtprovided by RGD
    Official Full Name
    oxytocin/neurophysin I prepropeptideprovided by RGD
    Primary source
    RGD:3238
    See related
    EnsemblRapid:ENSRNOG00000021225 AllianceGenome:RGD:3238
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables neuropeptide hormone activity and oxytocin receptor binding activity. Involved in several processes, including positive regulation of secretion by cell; positive regulation of smooth muscle contraction; and regulation of blood pressure. Located in extracellular space; secretory granule; and terminal bouton. Is active in neuronal dense core vesicle. Used to study gastric ulcer and hypertension. Biomarker of hypertension. Orthologous to human OXT (oxytocin/neurophysin I prepropeptide). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 36.9) See more
    Orthologs
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    Genomic context

    See Oxt in Genome Data Viewer
    Location:
    3q36
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (138235754..138236594)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (117782650..117783490)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (123106694..123107534)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, receptor type, A Neighboring gene uncharacterized LOC134486445 Neighboring gene mitochondrial ribosomal protein S26 Neighboring gene arginine vasopressin Neighboring gene U-box domain containing 5 Neighboring gene FAST kinase domains 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables V1A vasopressin receptor binding  
    enables neurohypophyseal hormone activity  
    enables neuropeptide hormone activity  
    enables neuropeptide hormone activity PubMed 
    enables neuropeptide hormone activity PubMed 
    enables oxytocin receptor binding  
    enables oxytocin receptor binding PubMed 
    enables protein binding PubMed 
    Items 1 - 25 of 50
    Process Evidence Code Pubs
    involved_in drinking behavior PubMed 
    involved_in eating behavior PubMed 
    involved_in female pregnancy PubMed 
    involved_in grooming behavior PubMed 
    involved_in heart development PubMed 
    involved_in lactation PubMed 
    involved_in male mating behavior PubMed 
    involved_in maternal aggressive behavior PubMed 
    involved_in maternal behavior PubMed 
    involved_in memory PubMed 
    involved_in negative regulation of blood pressure PubMed 
    involved_in negative regulation of urine volume PubMed 
    involved_in parturition PubMed 
    involved_in positive regulation of blood pressure PubMed 
    involved_in positive regulation of cold-induced thermogenesis  
    involved_in positive regulation of cold-induced thermogenesis PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration PubMed 
    involved_in positive regulation of female receptivity PubMed 
    involved_in positive regulation of hindgut contraction PubMed 
    involved_in positive regulation of norepinephrine secretion PubMed 
    involved_in positive regulation of ossification PubMed 
    involved_in positive regulation of penile erection PubMed 
    involved_in positive regulation of prostaglandin secretion PubMed 
    involved_in positive regulation of synapse assembly PubMed 
    involved_in positive regulation of synaptic transmission PubMed 
    involved_in positive regulation of uterine smooth muscle contraction PubMed 
    involved_in regulation of heart rate PubMed 
    involved_in response to activity PubMed 
    involved_in response to amphetamine PubMed 
    involved_in response to cAMP PubMed 
    involved_in response to cocaine PubMed 
    involved_in response to electrical stimulus PubMed 
    involved_in response to estradiol PubMed 
    involved_in response to ether PubMed 
    involved_in response to external biotic stimulus  
    involved_in response to food PubMed 
    involved_in response to food  
    involved_in response to glucocorticoid PubMed 
    involved_in response to mechanical stimulus  
    involved_in response to organic cyclic compound PubMed 
    involved_in response to organic cyclic compound PubMed 
    involved_in response to peptide hormone PubMed 
    involved_in response to progesterone PubMed 
    involved_in response to prostaglandin E PubMed 
    involved_in response to retinoic acid PubMed 
    involved_in response to steroid hormone PubMed 
    involved_in response to sucrose PubMed 
    involved_in signal transduction  
    involved_in social behavior PubMed 
    involved_in sperm ejaculation PubMed 
    Items 1 - 25 of 50
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in extracellular region  
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    is_active_in neuronal dense core vesicle PubMed 
    is_active_in secretory granule  
    located_in secretory granule PubMed 
    located_in terminal bouton PubMed 

    General protein information

    Preferred Names
    oxytocin-neurophysin 1
    Names
    OT-NPI
    oxcytocin
    oxytocin, prepropeptide
    oxytocin/neurophysin (Oxt) gene, complete gene, complete cds
    oxytocin/neurophysin 1 prepropeptide

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012996.3NP_037128.1  oxytocin-neurophysin 1 preproprotein

      See identical proteins and their annotated locations for NP_037128.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      P01179, Q53WU2
      Related
      ENSRNOP00000028829.3, ENSRNOT00000028829.7
      Conserved Domains (1) summary
      smart00003
      Location:39116
      NH; Neurohypophysial hormones

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      138235754..138236594
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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