Fat2 FAT atypical cadherin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fat2provided by RGD
Official Full Name: FAT atypical cadherin 2provided by RGD
Primary source: RGD:620656
See related: EnsemblRapid:ENSRNOG00000012575 AllianceGenome:RGD:620656
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fath2
Summary: Predicted to enable calcium ion binding activity. Involved in homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be located in Golgi apparatus and plasma membrane. Predicted to be active in adherens junction. Human ortholog(s) of this gene implicated in spinocerebellar ataxia 45. Orthologous to human FAT2 (FAT atypical cadherin 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 161.4) and Thymus (RPKM 46.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 10q22

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (39864765..39957027, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (39364072..39456324, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (40583025..40682598, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Got61 (e-PCR)
- UniSTS:114204

AI409913 (e-PCR)
- UniSTS:250438

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-substrate adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-substrate adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in epithelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IDA Inferred from Direct Assay more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in adherens junction	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protocadherin Fat 2

Names: FAT tumor suppressor homolog 2; MEGF1; multiple EGF-like domains protein 1; multiple epidermal growth factor-like domains 1; multiple epidermal growth factor-like domains protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022954.1 → NP_075243.1 protocadherin Fat 2 precursor

See identical proteins and their annotated locations for NP_075243.1

Status: PROVISIONAL

Source sequence(s)

AB011527

UniProtKB/Swiss-Prot

O88277

Related

ENSRNOP00000055459.5, ENSRNOT00000058665.6

Conserved Domains (6) summary

cd11304
Location:3328 → 3424

Cadherin_repeat; Cadherin tandem repeat domain

cd00054
Location:3953 → 3986

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00008
Location:3992 → 4022

EGF; EGF-like domain

pfam00028
Location:3433 → 3524

Cadherin; Cadherin domain

pfam02210
Location:3802 → 3923

Laminin_G_2; Laminin G domain

cl09101
Location:1877 → 1959

E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

39864765..39957027 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039086801.2 → XP_038942729.1 protocadherin Fat 2 isoform X1

UniProtKB/TrEMBL

F1LPM1

Conserved Domains (6) summary

cd11304
Location:3328 → 3424

Cadherin_repeat; Cadherin tandem repeat domain

cd00054
Location:3953 → 3986

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00008
Location:3992 → 4022

EGF; EGF-like domain

pfam00028
Location:3433 → 3524

Cadherin; Cadherin domain

pfam02210
Location:3802 → 3923

Laminin_G_2; Laminin G domain

cl29226
Location:1877 → 1959

Cadherin; Cadherin domain
XM_039086802.2 → XP_038942730.1 protocadherin Fat 2 isoform X1

UniProtKB/TrEMBL

F1LPM1

Conserved Domains (6) summary

cd11304
Location:3328 → 3424

Cadherin_repeat; Cadherin tandem repeat domain

cd00054
Location:3953 → 3986

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00008
Location:3992 → 4022

EGF; EGF-like domain

pfam00028
Location:3433 → 3524

Cadherin; Cadherin domain

pfam02210
Location:3802 → 3923

Laminin_G_2; Laminin G domain

cl29226
Location:1877 → 1959

Cadherin; Cadherin domain