Acy1 aminoacylase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Acy1provided by RGD
Official Full Name: aminoacylase 1provided by RGD
Primary source: RGD:2030
See related: EnsemblRapid:ENSRNOG00000011189 AllianceGenome:RGD:2030
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Acy1a; Acy1b
Summary: Enables aminoacylase activity. Predicted to be involved in protein catabolic process. Predicted to be located in extracellular exosome. Orthologous to human ACY1 (aminoacylase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 2160.4), Liver (RPKM 244.3) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (115951068..115956471, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (107072354..107077756, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (115134792..115140171, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings proposed ACY 1 as a new marker transcript for absorbing cells of intestinal crypt, which can be used to monitor the process of intestinal N-alpha-acetylated protein metabolism.[ACY 1]
Title: Acylase 1 expression in rat intestinal crypt--villus axis.
active site characterization
Title: Rat kidney acylase I: further characterisation and mutation studies on the involvement of Glu 147 in the catalytic process.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aminoacylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aminoacylase activity	IDA Inferred from Direct Assay more info	PubMed
enables aminoacylase activity	IEA Inferred from Electronic Annotation more info
enables aminoacylase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in amino acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in protein catabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: aminoacylase-1A

Names: ACY IA; ACY IB; ACY-1A; ACY-1B; N-acyl-L-amino-acid amidohydrolase; aminoacylase-1B

NP_001005383.2

EC 3.5.1.14

NP_001380767.1

EC 3.5.1.14

XP_063121307.1

EC 3.5.1.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005383.2 → NP_001005383.2 aminoacylase-1A

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

Q6AYS7, Q6PTT1

UniProtKB/TrEMBL

A0A8I5ZVF1

Related

ENSRNOP00000090917.2, ENSRNOT00000112946.2

Conserved Domains (1) summary

cd05646
Location:9 → 399

M20_AcylaseI_like; M20 Aminoacylase-I like subfamily
NM_001393838.1 → NP_001380767.1 aminoacylase-1A

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

Q6AYS7, Q6PTT1

UniProtKB/TrEMBL

A0A8I5ZVF1

Related

ENSRNOP00000082264.2, ENSRNOT00000103409.2

Conserved Domains (1) summary

cd05646
Location:9 → 399

M20_AcylaseI_like; M20 Aminoacylase-I like subfamily