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    Dusp14 dual specificity phosphatase 14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360580, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dusp14provided by RGD
    Official Full Name
    dual specificity phosphatase 14provided by RGD
    Primary source
    RGD:1307415
    See related
    EnsemblRapid:ENSRNOG00000030091 AllianceGenome:RGD:1307415
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dusp14l2
    Summary
    Predicted to enable MAP kinase tyrosine/serine/threonine phosphatase activity; myosin phosphatase activity; and protein tyrosine phosphatase activity. Predicted to be involved in protein dephosphorylation. Orthologous to human DUSP14 (dual specificity phosphatase 14). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 111.4), Brain (RPKM 75.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dusp14 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (69433949..69463863, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (68936483..68966347, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (71363688..71383602, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480841 Neighboring gene synergin, gamma Neighboring gene uncharacterized LOC134480839 Neighboring gene ribosomal protein S15a, pseudogene 2 Neighboring gene transcriptional adaptor 2A Neighboring gene similar to human chromosome 17 open reading frame 78 Neighboring gene acetyl-CoA carboxylase alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Enhancement of DUSP14 (dual specificity phosphatase 14) limits osteoarthritis progression by alleviating chondrocyte injury, inflammation and metabolic homeostasis. Zhao Z, et al. Bioengineered, 2021 Dec. PMID 34605731, Free PMC Article
    2. The Krüppel-Like Factor Gene Target Dusp14 Regulates Axon Growth and Regeneration. Galvao J, et al. Invest Ophthalmol Vis Sci, 2018 Jun 1. PMID 29860460, Free PMC Article
    3. Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10. Saad Y, et al. Genomics, 2007 Mar. PMID 17218081, Free PMC Article
    4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Enhancement of DUSP14 (dual specificity phosphatase 14) limits osteoarthritis progression by alleviating chondrocyte injury, inflammation and metabolic homeostasis.
      Title: Enhancement of DUSP14 (dual specificity phosphatase 14) limits osteoarthritis progression by alleviating chondrocyte injury, inflammation and metabolic homeostasis.
    2. These results link intrinsic and extrinsic regulators of axon growth and suggest modulation of the KLF9-Dusp14 pathway as a potential approach to improve regeneration in the adult CNS after injury.
      Title: The Krüppel-Like Factor Gene Target Dusp14 Regulates Axon Growth and Regeneration.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase tyrosine/serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS140 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity protein phosphatase 14
    Names
    dual specificity phosphatase 14-like 2
    NP_001073362.1
    NP_001257764.1
    NP_001257765.1
    XP_038942286.1
    XP_038942287.1
    XP_038942288.1
    XP_038942289.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079893.3 → NP_001073362.1  dual specificity protein phosphatase 14

      See identical proteins and their annotated locations for NP_001073362.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A1EC97, A6HHJ9, A6HHK0
      Conserved Domains (1) summary
      cd14572
      Location:20 → 169
      DUSP14; dual specificity protein phosphatase 14

    2. NM_001270835.2 → NP_001257764.1  dual specificity protein phosphatase 14

      See identical proteins and their annotated locations for NP_001257764.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A1EC97, A6HHJ9, A6HHK0
      Related
      ENSRNOP00000068350.3, ENSRNOT00000077025.4
      Conserved Domains (1) summary
      cd14572
      Location:20 → 169
      DUSP14; dual specificity protein phosphatase 14

    3. NM_001270836.2 → NP_001257765.1  dual specificity protein phosphatase 14

      See identical proteins and their annotated locations for NP_001257765.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A1EC97, A6HHJ9, A6HHK0
      Related
      ENSRNOP00000073504.1, ENSRNOT00000083300.3
      Conserved Domains (1) summary
      cd14572
      Location:20 → 169
      DUSP14; dual specificity protein phosphatase 14

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      69433949..69463863 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086361.2 → XP_038942289.1  dual specificity protein phosphatase 14 isoform X2

    2. XM_039086359.1 → XP_038942287.1  dual specificity protein phosphatase 14 isoform X1

      UniProtKB/TrEMBL
      A1EC97, A6HHJ9, A6HHK0
      Related
      ENSRNOP00000106797.1, ENSRNOT00000161103.1
      Conserved Domains (1) summary
      cd14572
      Location:20 → 169
      DUSP14; dual specificity protein phosphatase 14

    3. XM_039086358.2 → XP_038942286.1  dual specificity protein phosphatase 14 isoform X1

      UniProtKB/TrEMBL
      A1EC97, A6HHJ9, A6HHK0
      Conserved Domains (1) summary
      cd14572
      Location:20 → 169
      DUSP14; dual specificity protein phosphatase 14

    4. XM_039086360.2 → XP_038942288.1  dual specificity protein phosphatase 14 isoform X1

      UniProtKB/TrEMBL
      A1EC97, A6HHJ9, A6HHK0
      Conserved Domains (1) summary
      cd14572
      Location:20 → 169
      DUSP14; dual specificity protein phosphatase 14
    Nucleotide Protein Strain
    Heading Accession and Version

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