Prss21 serine protease 21 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prss21provided by RGD
Official Full Name: serine protease 21provided by RGD
Primary source: RGD:727870
See related: EnsemblRapid:ENSRNOG00000047969 AllianceGenome:RGD:727870
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Esp-1; Resp-1
Summary: Predicted to enable serine-type endopeptidase activity. Involved in spermatogenesis. Predicted to be located in membrane. Predicted to be active in extracellular space. Orthologous to human PRSS21 (serine protease 21). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 54.8) See more
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Genomic context

Location:: 10q12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (13404820..13410195)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (12899820..12905612)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (13214343..13219994)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a role in species-specific proteolytic events during spermatogenesis and fertilization
Title: Cloning, expression analysis, and tissue distribution of esp-1/testisin, a membrane-type serine protease from the rat.
Esp-1/Testisin plays a role in species-specific proteolytic events during spermatogenesis and fertilization.
Title: Cloning, expression analysis, and tissue distribution of esp-1/testisin, a membrane-type serine protease from the rat.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type peptidase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine protease 21

Names: eosinophil serine protease-1; protease, serine, 21; testisin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181477.3 → NP_852142.1 serine protease 21 precursor

See identical proteins and their annotated locations for NP_852142.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

Q80Z40

Related

ENSRNOP00000065300.3, ENSRNOT00000073065.4

Conserved Domains (2) summary

smart00020
Location:57 → 294

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:58 → 295

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

13404820..13410195

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006245872.5 → XP_006245934.1 serine protease 21 isoform X1

UniProtKB/TrEMBL

M0R778

Conserved Domains (2) summary

smart00020
Location:57 → 303

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:58 → 304

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_039086242.2 → XP_038942170.1 serine protease 21 isoform X2

Conserved Domains (1) summary

smart00020
Location:57 → 195

Tryp_SPc; Trypsin-like serine protease
XM_063269269.1 → XP_063125339.1 serine protease 21 isoform X2