U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Ryr2 ryanodine receptor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 689560, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ryr2provided by RGD
    Official Full Name
    ryanodine receptor 2provided by RGD
    Primary source
    RGD:620314
    See related
    EnsemblRapid:ENSRNOG00000017060 AllianceGenome:RGD:620314
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RyR; RYR-2
    Summary
    Enables ryanodine-sensitive calcium-release channel activity and scaffold protein binding activity. Involved in several processes, including metal ion transport; regulation of cytosolic calcium ion concentration; and response to magnesium ion. Located in several cellular components, including sarcolemma; sarcomere; and sarcoplasmic reticulum membrane. Is extrinsic component of cytoplasmic side of plasma membrane. Part of protein-containing complex. Used to study congestive heart failure. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy and catecholaminergic polymorphic ventricular tachycardia 1. Orthologous to human RYR2 (ryanodine receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 3084.4) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ryr2 in Genome Data Viewer
    Location:
    17q12.1
    Exon count:
    108
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (63081527..63667141)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (58389925..58975641)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (65533998..65955606, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5-like Neighboring gene 5-methyltetrahydrofolate-homocysteine methyltransferase Neighboring gene ribosomal protein S7, pseudogene 15 Neighboring gene small nucleolar RNA U3 Neighboring gene uncharacterized LOC134482861 Neighboring gene uncharacterized LOC134482862 Neighboring gene zona pellucida glycoprotein 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 28
    Function Evidence Code Pubs
    enables calcium channel activity  
    enables calcium channel activity  
    enables calcium ion binding  
    enables calcium-induced calcium release activity PubMed 
    enables calcium-induced calcium release activity  
    enables calmodulin binding  
    enables calmodulin binding  
    enables calmodulin binding  
    enables enzyme binding  
    enables identical protein binding  
    enables identical protein binding  
    enables intracellularly gated calcium channel activity  
    enables intracellularly gated calcium channel activity  
    enables organic cyclic compound binding  
    enables protein binding PubMed 
    enables protein kinase A catalytic subunit binding  
    enables protein kinase A catalytic subunit binding  
    enables protein kinase A regulatory subunit binding  
    enables protein kinase A regulatory subunit binding  
    enables protein kinase binding  
    enables ryanodine-sensitive calcium-release channel activity  
    enables ryanodine-sensitive calcium-release channel activity PubMed 
    enables ryanodine-sensitive calcium-release channel activity  
    enables ryanodine-sensitive calcium-release channel activity PubMed 
    enables ryanodine-sensitive calcium-release channel activity  
    enables scaffold protein binding PubMed 
    enables suramin binding  
    enables suramin binding  
    Items 1 - 25 of 28
    Items 1 - 25 of 87
    Process Evidence Code Pubs
    involved_in Purkinje myocyte to ventricular cardiac muscle cell signaling  
    involved_in Purkinje myocyte to ventricular cardiac muscle cell signaling  
    acts_upstream_of_or_within calcium ion transmembrane import into cytosol  
    involved_in calcium ion transmembrane transport  
    involved_in calcium ion transmembrane transport PubMed 
    acts_upstream_of_or_within calcium ion transmembrane transport  
    acts_upstream_of_or_within calcium ion transport  
    involved_in calcium ion transport  
    involved_in calcium ion transport  
    involved_in calcium ion transport into cytosol  
    involved_in calcium ion transport into cytosol  
    involved_in calcium-mediated signaling  
    involved_in calcium-mediated signaling  
    involved_in calcium-mediated signaling  
    involved_in cardiac muscle contraction  
    involved_in cardiac muscle hypertrophy  
    acts_upstream_of_or_within cardiac muscle hypertrophy  
    involved_in cellular response to caffeine  
    acts_upstream_of_or_within cellular response to caffeine  
    involved_in cellular response to caffeine  
    involved_in cellular response to caffeine  
    involved_in cellular response to epinephrine stimulus  
    involved_in cellular response to epinephrine stimulus  
    involved_in detection of calcium ion  
    involved_in detection of calcium ion  
    involved_in embryonic heart tube morphogenesis  
    involved_in embryonic heart tube morphogenesis  
    involved_in embryonic heart tube morphogenesis  
    involved_in establishment of localization in cell  
    acts_upstream_of_or_within establishment of localization in cell  
    involved_in establishment of protein localization to endoplasmic reticulum  
    involved_in establishment of protein localization to endoplasmic reticulum  
    involved_in intracellular calcium ion homeostasis  
    involved_in intracellular calcium ion homeostasis  
    involved_in intracellular calcium ion homeostasis  
    involved_in left ventricular cardiac muscle tissue morphogenesis  
    acts_upstream_of_or_within left ventricular cardiac muscle tissue morphogenesis  
    involved_in manganese ion transmembrane transport PubMed 
    involved_in monoatomic ion transmembrane transport PubMed 
    involved_in negative regulation of cytosolic calcium ion concentration PubMed 
    involved_in positive regulation of heart rate  
    acts_upstream_of_or_within positive regulation of heart rate  
    involved_in positive regulation of sequestering of calcium ion  
    involved_in positive regulation of sequestering of calcium ion  
    involved_in positive regulation of the force of heart contraction  
    involved_in positive regulation of the force of heart contraction  
    involved_in regulation of AV node cell action potential  
    involved_in regulation of AV node cell action potential  
    involved_in regulation of SA node cell action potential  
    involved_in regulation of SA node cell action potential  
    involved_in regulation of atrial cardiac muscle cell action potential  
    involved_in regulation of atrial cardiac muscle cell action potential  
    involved_in regulation of cardiac muscle contraction  
    involved_in regulation of cardiac muscle contraction by calcium ion signaling  
    involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  
    involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  
    involved_in regulation of cytosolic calcium ion concentration PubMed 
    involved_in regulation of heart rate  
    involved_in regulation of ventricular cardiac muscle cell action potential  
    involved_in regulation of ventricular cardiac muscle cell action potential  
    involved_in release of sequestered calcium ion into cytosol  
    involved_in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  
    involved_in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  
    acts_upstream_of_or_within release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  
    involved_in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  
    involved_in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  
    acts_upstream_of_or_within response to caffeine  
    involved_in response to caffeine  
    involved_in response to calcium ion PubMed 
    involved_in response to hypoxia  
    involved_in response to hypoxia PubMed 
    involved_in response to hypoxia  
    involved_in response to magnesium ion PubMed 
    involved_in response to muscle activity  
    involved_in response to muscle activity  
    involved_in response to muscle stretch  
    involved_in response to muscle stretch  
    involved_in response to nutrient PubMed 
    involved_in response to redox state  
    involved_in response to redox state  
    involved_in response to xenobiotic stimulus PubMed 
    involved_in sarcoplasmic reticulum calcium ion transport PubMed 
    involved_in striated muscle contraction  
    involved_in type B pancreatic cell apoptotic process  
    involved_in type B pancreatic cell apoptotic process  
    involved_in ventricular cardiac muscle cell action potential  
    involved_in ventricular cardiac muscle cell action potential  
    Items 1 - 25 of 87
    Items 1 - 20 of 27
    Component Evidence Code Pubs
    located_in A band PubMed 
    is_active_in Z disc  
    located_in Z disc PubMed 
    located_in Z disc  
    located_in Z disc  
    part_of calcium channel complex  
    part_of calcium channel complex  
    part_of calcium channel complex  
    located_in extrinsic component of cytoplasmic side of plasma membrane PubMed 
    located_in membrane  
    located_in nuclear envelope PubMed 
    part_of protein-containing complex PubMed 
    part_of protein-containing complex  
    part_of protein-containing complex  
    is_active_in sarcolemma  
    located_in sarcolemma PubMed 
    located_in sarcomere  
    located_in sarcoplasmic reticulum PubMed 
    located_in sarcoplasmic reticulum  
    is_active_in sarcoplasmic reticulum membrane  
    located_in sarcoplasmic reticulum membrane PubMed 
    located_in sarcoplasmic reticulum membrane  
    located_in sarcoplasmic reticulum membrane  
    is_active_in sarcoplasmic reticulum membrane  
    is_active_in smooth endoplasmic reticulum  
    located_in smooth endoplasmic reticulum  
    located_in smooth endoplasmic reticulum  
    Items 1 - 20 of 27

    General protein information

    Preferred Names
    ryanodine receptor 2
    Names
    cardiac muscle ryanodine receptor
    cardiac muscle ryanodine receptor-calcium release channel
    cardiac-type ryaodine receptor
    ryanodine receptor 2, cardiac
    ryanodine receptor type II
    type 2 ryanodine receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191043.3NP_001177972.2  ryanodine receptor 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/Swiss-Prot
      B0LPN4, D7UNT3
      Conserved Domains (11) summary
      cd12877
      Location:647798
      SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
      cd12878
      Location:10791211
      SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
      cd12879
      Location:14051552
      SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
      pfam00520
      Location:46984858
      Ion_trans; Ion transport protein
      pfam01365
      Location:448641
      RYDR_ITPR; RIH domain
      pfam02026
      Location:26932783
      RyR; RyR domain
      pfam02815
      Location:219399
      MIR; MIR domain
      pfam06459
      Location:43144579
      RR_TM4-6; Ryanodine Receptor TM 4-6
      pfam08454
      Location:38113928
      RIH_assoc; RyR and IP3R Homology associated
      pfam13499
      Location:40124067
      EF-hand_7; EF-hand domain pair
      cl19745
      Location:9215
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    2. NM_032078.3NP_114467.2  ryanodine receptor 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/Swiss-Prot
      B0LPN4, D7UNT3
      UniProtKB/TrEMBL
      F1LS89
      Related
      ENSRNOP00000108473.1, ENSRNOT00000158171.1
      Conserved Domains (5) summary
      smart00472
      Location:279369
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      cd12877
      Location:647798
      SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
      cd12878
      Location:10791211
      SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
      cd12879
      Location:14051552
      SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
      cl08302
      Location:40184073
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      63081527..63667141
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276749.1XP_063132819.1  ryanodine receptor 2 isoform X1

      UniProtKB/Swiss-Prot
      B0LPN4, D7UNT3
    2. XM_063276751.1XP_063132821.1  ryanodine receptor 2 isoform X3

      UniProtKB/Swiss-Prot
      B0LPN4, D7UNT3
    3. XM_063276756.1XP_063132826.1  ryanodine receptor 2 isoform X8

      UniProtKB/Swiss-Prot
      B0LPN4, D7UNT3
    4. XM_063276752.1XP_063132822.1  ryanodine receptor 2 isoform X4

      UniProtKB/Swiss-Prot
      B0LPN4, D7UNT3
    5. XM_063276757.1XP_063132827.1  ryanodine receptor 2 isoform X9

      UniProtKB/Swiss-Prot
      B0LPN4, D7UNT3
    6. XM_063276754.1XP_063132824.1  ryanodine receptor 2 isoform X6

      UniProtKB/Swiss-Prot
      B0LPN4, D7UNT3
    7. XM_063276758.1XP_063132828.1  ryanodine receptor 2 isoform X10

      UniProtKB/Swiss-Prot
      B0LPN4, D7UNT3
    8. XM_063276753.1XP_063132823.1  ryanodine receptor 2 isoform X5

      UniProtKB/Swiss-Prot
      B0LPN4, D7UNT3
    9. XM_063276762.1XP_063132832.1  ryanodine receptor 2 isoform X14

      UniProtKB/Swiss-Prot
      B0LPN4, D7UNT3
    10. XM_063276763.1XP_063132833.1  ryanodine receptor 2 isoform X15

      UniProtKB/Swiss-Prot
      B0LPN4, D7UNT3
    11. XM_063276759.1XP_063132829.1  ryanodine receptor 2 isoform X11

      UniProtKB/Swiss-Prot
      B0LPN4, D7UNT3
      UniProtKB/TrEMBL
      F1LRZ1
      Related
      ENSRNOP00000023601.7, ENSRNOT00000023601.9
    12. XM_063276760.1XP_063132830.1  ryanodine receptor 2 isoform X12

      UniProtKB/Swiss-Prot
      B0LPN4, D7UNT3
    13. XM_063276750.1XP_063132820.1  ryanodine receptor 2 isoform X2

      UniProtKB/Swiss-Prot
      B0LPN4, D7UNT3
    14. XM_063276755.1XP_063132825.1  ryanodine receptor 2 isoform X7

      UniProtKB/Swiss-Prot
      B0LPN4, D7UNT3
    15. XM_063276764.1XP_063132834.1  ryanodine receptor 2 isoform X16

      UniProtKB/Swiss-Prot
      B0LPN4, D7UNT3
      Related
      ENSRNOP00000087428.1, ENSRNOT00000111439.2
    16. XM_063276761.1XP_063132831.1  ryanodine receptor 2 isoform X13

      UniProtKB/TrEMBL
      A6KN28

    RNA

    1. XR_005495333.2 RNA Sequence

    2. XR_010058952.1 RNA Sequence

    External link. Please review our privacy policy.