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    Ripk4 receptor-interacting serine-threonine kinase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304053, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ripk4provided by RGD
    Official Full Name
    receptor-interacting serine-threonine kinase 4provided by RGD
    Primary source
    RGD:1311691
    See related
    EnsemblRapid:ENSRNOG00000001618 AllianceGenome:RGD:1311691
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein serine kinase activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including positive regulation of NF-kappaB transcription factor activity; protein phosphorylation; and skin development. Predicted to be active in cytoplasm. Orthologous to human RIPK4 (receptor interacting serine/threonine kinase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 71.9), Liver (RPKM 58.9) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ripk4 in Genome Data Viewer
    Location:
    11q12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (50591926..50614169, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (37122555..37144799, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (38251991..38274234, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene ornithine decarboxylase antizyme 1, pseudogene 1 Neighboring gene uncharacterized LOC108352390 Neighboring gene PR/SET domain 15 Neighboring gene C2 calcium-dependent domain containing 2 Neighboring gene uncharacterized LOC134480980

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Exome sequence identifies RIPK4 as the Bartsocas-Papas syndrome locus. Mitchell K, et al. Am J Hum Genet, 2012 Jan 13. PMID 22197488, Free PMC Article
    2. cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4). Bertrand MJ, et al. PLoS One, 2011. PMID 21931591, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in morphogenesis of an epithelium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in skin development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in skin development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    receptor-interacting serine/threonine-protein kinase 4
    XP_017453501.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107103.2 → NP_001100573.2  receptor-interacting serine/threonine-protein kinase 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A6IQH3, D4AAK5
      Related
      ENSRNOP00000002206.2, ENSRNOT00000002206.7

    2. NM_001433915.1 → NP_001420844.1  receptor-interacting serine/threonine-protein kinase 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A6IQH3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      50591926..50614169 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017598012.2 → XP_017453501.1  receptor-interacting serine/threonine-protein kinase 4 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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