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    Erp44 endoplasmic reticulum protein 44 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298066, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Erp44provided by RGD
    Official Full Name
    endoplasmic reticulum protein 44provided by RGD
    Primary source
    RGD:1309176
    See related
    EnsemblRapid:ENSRNOG00000005841 AllianceGenome:RGD:1309176
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    BWK4; Txndc4
    Summary
    Predicted to enable protein disulfide isomerase activity. Predicted to be involved in several processes, including protein folding; response to endoplasmic reticulum stress; and response to unfolded protein. Predicted to be located in cell surface and endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum membrane and endoplasmic reticulum-Golgi intermediate compartment. Orthologous to human ERP44 (endoplasmic reticulum protein 44). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 461.5), Liver (RPKM 298.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Erp44 in Genome Data Viewer
    Location:
    5q22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (67313245..67406207, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (62516550..62610762, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (63937866..64030827, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134478966 Neighboring gene nuclear receptor subfamily 4, group A, member 3 Neighboring gene syntaxin 17 Neighboring gene exosome component 8, pseudogene 1 Neighboring gene inversin Neighboring gene uncharacterized LOC102551711 Neighboring gene testis expressed 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ERp44, a novel endoplasmic reticulum folding assistant of the thioredoxin family. Anelli T, et al. EMBO J, 2002 Feb 15. PMID 11847130, Free PMC Article
    2. Insights into role of bromodomain, testis-specific (Brdt) in acetylated histone H4-dependent chromatin remodeling in mammalian spermiogenesis. Dhar S, et al. J Biol Chem, 2012 Feb 24. PMID 22215678, Free PMC Article
    3. Platelets release novel thiol isomerase enzymes which are recruited to the cell surface following activation. Holbrook LM, et al. Br J Haematol, 2010 Feb. PMID 19995400
    4. Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46. Breuza L, et al. J Biol Chem, 2004 Nov 5. PMID 15308636
    5. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein disulfide isomerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycoprotein metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein folding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to unfolded protein ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    endoplasmic reticulum resident protein 44
    Names
    thioredoxin domain containing 4 (endoplasmic reticulum)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008317.2 → NP_001008318.1  endoplasmic reticulum resident protein 44 precursor

      See identical proteins and their annotated locations for NP_001008318.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6KJF6, F7FLN3, Q5VLR5
      Related
      ENSRNOP00000007711.3, ENSRNOT00000007711.7
      Conserved Domains (4) summary
      cd02996
      Location:29 → 136
      PDI_a_ERp44; PDIa family, endoplasmic reticulum protein 44 (ERp44) subfamily; ERp44 is an ER-resident protein, induced during stress, involved in thiol-mediated ER retention. It contains an N-terminal TRX domain, similar to that of PDIa, with a CXFS motif followed by ...
      cd03070
      Location:144 → 234
      PDI_b_ERp44; PDIb family, ERp44 subfamily, first redox inactive TRX-like domain b; ERp44 is an endoplasmic reticulum (ER)-resident protein, induced during stress, involved in thiol-mediated ER retention. It contains an N-terminal TRX domain with a CXFS motif followed ...
      cd03072
      Location:245 → 355
      PDI_b'_ERp44; PDIb' family, ERp44 subfamily, second redox inactive TRX-like domain b'; ERp44 is an endoplasmic reticulum (ER)-resident protein, induced during stress, involved in thiol-mediated ER retention. It contains an N-terminal TRX domain with a CXFS motif ...
      pfam13848
      Location:167 → 350
      Thioredoxin_6; Thioredoxin-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      67313245..67406207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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