Pecr peroxisomal trans-2-enoyl-CoA reductase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pecrprovided by RGD
Official Full Name: peroxisomal trans-2-enoyl-CoA reductaseprovided by RGD
Primary source: RGD:70925
See related: EnsemblRapid:ENSRNOG00000055295 AllianceGenome:RGD:70925
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: TERP
Summary: Predicted to enable signaling receptor binding activity and trans-2-enoyl-CoA reductase (NADPH) activity. Predicted to be involved in phytol metabolic process. Located in peroxisome. Orthologous to human PECR (peroxisomal trans-2-enoyl-CoA reductase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 1772.4), Kidney (RPKM 566.9) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q33

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (81347170..81375809, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (73897877..73926511, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (79601937..79630547, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that 2,4-dienoyl-CoA reductase and hydroxymethylglutaryl-CoA synthase (HMGCS2) were upregulated in alcohol-fed rats.
Title: Overexpression of hydroxymethylglutaryl CoA synthase 2 and 2,4-dienoyl-CoA reductase in rat pancreas following chronic alcohol consumption.

Submit: New GeneRIF Correction

General gene information

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Markers

RH144097 (e-PCR)
- UniSTS:233343

AU028733 (e-PCR)
- UniSTS:112040

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
NOT enables 2,4-dienoyl-CoA reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables trans-2-enoyl-CoA reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables trans-2-enoyl-CoA reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables trans-2-enoyl-CoA reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info
enables trans-2-enoyl-CoA reductase (NADPH) activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phytol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phytol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phytol metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in peroxisomal membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IEA Inferred from Electronic Annotation more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peroxisomal trans-2-enoyl-CoA reductase

Names: PX-2,4-DCR1; RLF98; perosisomal 2-enoyl-CoA reductase; peroxisomal 2,4-dienoyl-CoA reductase

NP_579833.1

EC 1.3.1.38

XP_063122601.1

EC 1.3.1.38

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133299.2 → NP_579833.1 peroxisomal trans-2-enoyl-CoA reductase

See identical proteins and their annotated locations for NP_579833.1

Status: PROVISIONAL

Source sequence(s)

AF021854

UniProtKB/Swiss-Prot

Q9WVK3

UniProtKB/TrEMBL

A0A8I6ATH4, A6KFH7

Related

ENSRNOP00000073815.2, ENSRNOT00000089283.3

Conserved Domains (2) summary

cd05369
Location:16 → 267

TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR

PRK05653
Location:15 → 267

fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Validated