Il13ra2 interleukin 13 receptor subunit alpha 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Il13ra2provided by RGD
Official Full Name: interleukin 13 receptor subunit alpha 2provided by RGD
Primary source: RGD:620838
See related: EnsemblRapid:ENSRNOG00000032973 AllianceGenome:RGD:620838
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: IL-13R-alpha-2
Summary: Predicted to enable cytokine binding activity and cytokine receptor activity. Involved in cellular response to mechanical stimulus. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Used to study steatotic liver disease. Human ortholog(s) of this gene implicated in breast cancer and pancreatic cancer. Orthologous to human IL13RA2 (interleukin 13 receptor subunit alpha 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Uterus (RPKM 50.9), Spleen (RPKM 13.2) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq34

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (115814620..115886080, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (111002590..111074053, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (118443955..118514716, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

M2a Macrophage-Secreted CHI3L1 Promotes Extracellular Matrix Metabolic Imbalances via Activation of IL-13Ralpha2/MAPK Pathway in Rat Intervertebral Disc Degeneration.
Title: M2a Macrophage-Secreted CHI3L1 Promotes Extracellular Matrix Metabolic Imbalances via Activation of IL-13Rα2/MAPK Pathway in Rat Intervertebral Disc Degeneration.
gene sequence and tissue distribution of IL-13Ralpha2 in the rat
Title: Molecular cloning of the rat IL-13 alpha 2 receptor cDNA and its expression in rat tissues.
IL13ra2 was upregulated in Il13-mediated minimal-change-like nephropathy.
Title: Overexpression of interleukin-13 induces minimal-change-like nephropathy in rats.

Submit: New GeneRIF Correction

General gene information

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Markers

D11Bhm88 (e-PCR), detects polymorphism
- UniSTS:141695

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	IEA Inferred from Electronic Annotation more info
enables cytokine receptor activity	ISO Inferred from Sequence Orthology more info
enables cytokine receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in immunoglobulin mediated immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immunoglobulin mediated immune response	ISO Inferred from Sequence Orthology more info
involved_in interleukin-13-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of immunoglobulin production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of immunoglobulin production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mast cell degranulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of mast cell degranulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: interleukin-13 receptor subunit alpha-2

Names: IL-13 receptor subunit alpha-2; IL-13R subunit alpha-2; interleukin 13 receptor, alpha 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133538.2 → NP_598222.2 interleukin-13 receptor subunit alpha-2 precursor

See identical proteins and their annotated locations for NP_598222.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

Q8VHK6

UniProtKB/TrEMBL

A6KGB0, G3V9B6

Conserved Domains (1) summary

pfam09240
Location:138 → 231

IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

115814620..115886080 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039099436.2 → XP_038955364.1 interleukin-13 receptor subunit alpha-2 isoform X1

UniProtKB/Swiss-Prot

Q8VHK6

UniProtKB/TrEMBL

A6KGB0, G3V9B6

Related

ENSRNOP00000041564.3, ENSRNOT00000043338.7

Conserved Domains (1) summary

pfam09240
Location:138 → 231

IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
XM_006257427.4 → XP_006257489.1 interleukin-13 receptor subunit alpha-2 isoform X1

See identical proteins and their annotated locations for XP_006257489.1

UniProtKB/Swiss-Prot

Q8VHK6

UniProtKB/TrEMBL

A6KGB0, G3V9B6

Conserved Domains (1) summary

pfam09240
Location:138 → 231

IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
XM_063279768.1 → XP_063135838.1 interleukin-13 receptor subunit alpha-2 isoform X1

UniProtKB/Swiss-Prot

Q8VHK6

UniProtKB/TrEMBL

A6KGB0, G3V9B6

Related

ENSRNOP00000104947.1, ENSRNOT00000166113.1