Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Aticprovided by RGD
Full Name: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolaseprovided by RGD
Primary source: RGD:70879
See related: EnsemblRapid:ENSRNOG00000015511 AllianceGenome:RGD:70879
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables IMP cyclohydrolase activity and phosphoribosylaminoimidazolecarboxamide formyltransferase activity. Involved in several processes, including 'de novo' IMP biosynthetic process; brain development; and dihydrofolate metabolic process. Predicted to be located in plasma membrane. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in purine-pyrimidine metabolic disorder. Orthologous to human ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 265.9), Thymus (RPKM 234.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q33

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (80614311..80634360)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (73164846..73184897)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (78862013..78882061)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Independent and combined effects of calorie restriction and AICAR on glucose uptake and insulin signaling in skeletal muscles from 24-month-old female and male rats.
Title: Independent and combined effects of calorie restriction and AICAR on glucose uptake and insulin signaling in skeletal muscles from 24-month-old female and male rats.
Data identified ATIC as a physical partner of internalized insulin receptor (IR) in purified Golgi-endosomes (G/E) fractions of rat's liver. They show that ATIC later accumulates in G/E . SiRNA-mediated partial knockdown of ATIC decreased tyrosine phosphorylation of IR and regulated IR endocytosis in HEK293 cells. Treatment with ATIC substrate AICAR, which is an allosteric activator of AMPK, increased IR endocytosis.
Title: The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein network.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables IMP cyclohydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables IMP cyclohydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables IMP cyclohydrolase activity	IEA Inferred from Electronic Annotation more info
enables IMP cyclohydrolase activity	ISO Inferred from Sequence Orthology more info
enables phosphoribosylaminoimidazolecarboxamide formyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphoribosylaminoimidazolecarboxamide formyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphoribosylaminoimidazolecarboxamide formyltransferase activity	IEA Inferred from Electronic Annotation more info
enables phosphoribosylaminoimidazolecarboxamide formyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in 'de novo' AMP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in 'de novo' IMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in 'de novo' IMP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in 'de novo' IMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in 'de novo' IMP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in 'de novo' XMP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in GMP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in animal organ regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in brainstem development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cellular response to interleukin-7	ISO Inferred from Sequence Orthology more info
involved_in cerebellum development	IEP Inferred from Expression Pattern more info	PubMed
involved_in cerebral cortex development	IEP Inferred from Expression Pattern more info	PubMed
involved_in dihydrofolate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in tetrahydrofolate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: bifunctional purine biosynthesis protein ATIC

Names: AICAR transformylase/inosine monophosphate cyclohydrolase; bifunctional purine biosynthesis protein PURH; bifunctional purine biosynthesis protein PURH-like

NP_112276.2

EC 2.1.2.3

EC 3.5.4.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031014.2 → NP_112276.2 bifunctional purine biosynthesis protein ATIC

See identical proteins and their annotated locations for NP_112276.2

Status: PROVISIONAL

Source sequence(s)

BC072496

UniProtKB/Swiss-Prot

O35567, Q6IN16

UniProtKB/TrEMBL

A0A8L2QB21, A6KFG3

Related

ENSRNOP00000078278.1, ENSRNOT00000116844.2

Conserved Domains (3) summary

PRK07106
Location:203 → 592

PRK07106; 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional

COG0138
Location:7 → 592

PurH; AICAR transformylase/IMP cyclohydrolase PurH [Nucleotide transport and metabolism]

cd01421
Location:5 → 193

IMPCH; Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates ...