Impg2 interphotoreceptor matrix proteoglycan 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Impg2provided by RGD
Official Full Name: interphotoreceptor matrix proteoglycan 2provided by RGD
Primary source: RGD:708358
See related: EnsemblRapid:ENSRNOG00000001616 AllianceGenome:RGD:708358
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pg10.2
Summary: Predicted to enable heparin binding activity and hyaluronic acid binding activity. Predicted to be involved in visual perception. Predicted to act upstream of or within extracellular matrix organization; protein localization; and retina morphogenesis in camera-type eye. Predicted to be located in interphotoreceptor matrix. Predicted to be part of receptor complex. Human ortholog(s) of this gene implicated in retinitis pigmentosa 56 and vitelliform macular dystrophy. Orthologous to human IMPG2 (interphotoreceptor matrix proteoglycan 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 6.3), Brain (RPKM 5.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q12

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (57787914..57887450, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (44318836..44418382, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (46615091..46693565, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables heparin binding	IBA Inferred from Biological aspect of Ancestor more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables hyaluronic acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables hyaluronic acid binding	IEA Inferred from Electronic Annotation more info
enables hyaluronic acid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in extracellular matrix organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within extracellular matrix organization	ISO Inferred from Sequence Orthology more info
involved_in protein localization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info
involved_in retina morphogenesis in camera-type eye	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within retina morphogenesis in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in interphotoreceptor matrix	IEA Inferred from Electronic Annotation more info
located_in interphotoreceptor matrix	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in photoreceptor inner segment	IEA Inferred from Electronic Annotation more info
located_in photoreceptor outer segment	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IEA Inferred from Electronic Annotation more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interphotoreceptor matrix proteoglycan 2

Names: sialoprotein associated with cones and rods proteoglycan; spacrcan

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_139088.4 → NP_620788.2 interphotoreceptor matrix proteoglycan 2 precursor

See identical proteins and their annotated locations for NP_620788.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/Swiss-Prot

P70628

UniProtKB/TrEMBL

A6IQP7

Related

ENSRNOP00000046981.6, ENSRNOT00000044900.6

Conserved Domains (2) summary

smart00200
Location:895 → 1018

SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

cl02507
Location:235 → 345

SEA; SEA domain