Gabarap GABA type A receptor-associated protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gabarapprovided by RGD
Official Full Name: GABA type A receptor-associated proteinprovided by RGD
Primary source: RGD:61911
See related: AllianceGenome:RGD:61911
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables GABA receptor binding activity. Predicted to be involved in several processes, including macroautophagy; positive regulation of protein metabolic process; and regulation of neurotransmitter receptor localization to postsynaptic specialization membrane. Predicted to act upstream of or within microtubule cytoskeleton organization. Located in cell body and perinuclear region of cytoplasm. Is active in GABA-ergic synapse and postsynaptic specialization, intracellular component. Orthologous to human GABARAP (GABA type A receptor-associated protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 1314.7), Testes (RPKM 947.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (55213465..55216787)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (54714777..54718099)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (56601288..56604223)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Macroautophagic sequestration does not require the LC3 subfamily but the GABARAP subfamily is essential.
Title: Autophagic bulk sequestration of cytosolic cargo is independent of LC3, but requires GABARAPs.
These results support the regulatory role of Bcl-2 in autophagy and define GABARAP as a novel interaction partner involved in this intricate connection.
Title: Interaction of Bcl-2 with the autophagy-related GABAA receptor-associated protein (GABARAP): biophysical characterization and functional implications.
GABARAP and AT(1)R interact through discrete domains and this association regulates the cell-surface accumulation and, consequently, ligand-induced function of the receptor.
Title: C-terminal processing of GABARAP is not required for trafficking of the angiotensin II type 1A receptor.
The results of this study show that GABARAP has a functional effect on the trafficking of GABA(A) receptors and provide evidence for the role of GABARAP in transporting GABA(A) receptors to the plasma membrane in neurons.
Title: GABAA receptor-associated protein traffics GABAA receptors to the plasma membrane in neurons.
Coexpression of GABARAP increases the steady-state expression of GABA-A receptors at the cell surface. Coexpression of GABARAP increases GABA currents by 2- to 3-fold.
Title: GABAA receptor-associated protein regulates GABAA receptor cell-surface number in Xenopus laevis oocytes.
Carboxyl-terminal processing of GABARAP is essential for the localization of GABARAP and its functions as a trafficking protein.
Title: C-terminal modification is required for GABARAP-mediated GABA(A) receptor trafficking.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH128955 (e-PCR)
- UniSTS:212263

UniSTS:224312 (e-PCR)
- UniSTS:224312

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GABA receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables GABA receptor binding	IEA Inferred from Electronic Annotation more info
enables GABA receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables GABA receptor binding	ISO Inferred from Sequence Orthology more info
enables beta-tubulin binding	IEA Inferred from Electronic Annotation more info
enables beta-tubulin binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylethanolamine binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylethanolamine binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylethanolamine binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in cellular response to nitrogen starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in extrinsic apoptotic signaling pathway via death domain receptors	IEA Inferred from Electronic Annotation more info
involved_in extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway via death domain receptors	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in mitophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein K48-linked ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein K48-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of Rac protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of Rac protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of Rac protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in autophagosome	IEA Inferred from Electronic Annotation more info
located_in autophagosome	ISO Inferred from Sequence Orthology more info
located_in autophagosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in autophagosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in autophagosome membrane	IEA Inferred from Electronic Annotation more info
located_in autophagosome membrane	ISO Inferred from Sequence Orthology more info
located_in axoneme	ISO Inferred from Sequence Orthology more info
located_in axoneme	ISS Inferred from Sequence or Structural Similarity more info
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
part_of microtubule associated complex	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic specialization, intracellular component	IDA Inferred from Direct Assay more info	PubMed
located_in smooth endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in sperm midpiece	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: gamma-aminobutyric acid receptor-associated protein

Names: GABA(A) receptor-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172036.4 → NP_742033.1 gamma-aminobutyric acid receptor-associated protein

See identical proteins and their annotated locations for NP_742033.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

P60517

UniProtKB/TrEMBL

A6HFZ8

Conserved Domains (1) summary

cd17232
Location:2 → 116

Ubl_ATG8_GABARAP; ubiquitin-like (Ubl) domain found in gamma-aminobutyric acid receptor-associated protein (GABARAP)