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    Nnt nicotinamide nucleotide transhydrogenase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310378, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nntprovided by RGD
    Official Full Name
    nicotinamide nucleotide transhydrogenaseprovided by RGD
    Primary source
    RGD:1587346
    See related
    EnsemblRapid:ENSRNOG00000026842 AllianceGenome:RGD:1587346
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable NADP binding activity. Involved in several processes, including cell redox homeostasis; intracellular oxygen homeostasis; and positive regulation of hydrogen peroxide catabolic process. Predicted to be located in mitochondrion. Biomarker of obesity. Human ortholog(s) of this gene implicated in familial glucocorticoid deficiency. Orthologous to human NNT (nicotinamide nucleotide transhydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 2590.3), Muscle (RPKM 852.4) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nnt in Genome Data Viewer
    Location:
    2q15
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (53144157..53237857, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (51411413..51505125, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (52189523..52283095, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene ferritin light chain 1 like 6 Neighboring gene small nucleolar RNA SNORD36 Neighboring gene 60S ribosomal protein L15 pseudogene Neighboring gene poly(A) binding protein interacting protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Vitamin E and vitamin C do not reduce insulin sensitivity but inhibit mitochondrial protein expression in exercising obese rats. Picklo MJ, et al. Appl Physiol Nutr Metab, 2015 Apr. PMID 25761734, Free PMC Article
    2. Nicotinamide nucleotide transhydrogenase (Nnt) links the substrate requirement in brain mitochondria for hydrogen peroxide removal to the thioredoxin/peroxiredoxin (Trx/Prx) system. Lopert P, et al. J Biol Chem, 2014 May 30. PMID 24722990, Free PMC Article
    3. Silencing of nicotinamide nucleotide transhydrogenase impairs cellular redox homeostasis and energy metabolism in PC12 cells. Yin F, et al. Biochim Biophys Acta, 2012 Mar. PMID 22198343, Free PMC Article
    4. The high-resolution structure of the NADP(H)-binding component (dIII) of proton-translocating transhydrogenase from human heart mitochondria. White SA, et al. Structure, 2000 Jan 15. PMID 10673423
    5. Mutations in NNT encoding nicotinamide nucleotide transhydrogenase cause familial glucocorticoid deficiency. Meimaridou E, et al. Nat Genet, 2012 May 27. PMID 22634753, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nnt is the critical link between the metabolic and H2O2 antioxidant function in brain mitochondria and is a potential therapeutic target to improve the redox balance in conditions of oxidative stress associated with neurodegenerative diseases.
      Title: Nicotinamide nucleotide transhydrogenase (Nnt) links the substrate requirement in brain mitochondria for hydrogen peroxide removal to the thioredoxin/peroxiredoxin (Trx/Prx) system.
    2. Disruption of electron flux from fuel substrates to redox components due to NNT suppression induces not only mitochondrial dysfunction but also cellular disorders through redox-sensitive signaling.
      Title: Silencing of nicotinamide nucleotide transhydrogenase impairs cellular redox homeostasis and energy metabolism in PC12 cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109126

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NADP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NADP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proton-translocating NAD(P)+ transhydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NADPH regeneration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NADPH regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell redox homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular oxidant detoxification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular oxygen homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of hydrogen peroxide catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitochondrial membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to vitamin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    NAD(P) transhydrogenase, mitochondrial
    Names
    Nicotinamide nucleotide transhydrogenase (NAD(P)+ transhydrogenase)
    NP_001013175.1
    XP_006232030.1
    XP_006232031.1
    XP_006232032.1
    XP_006232033.1
    XP_006232034.1
    XP_008758996.1
    XP_038958184.1
    XP_038958185.1
    XP_063137853.1
    XP_063137854.1
    XP_063137855.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013157.1 → NP_001013175.1  NAD(P) transhydrogenase, mitochondrial

      See identical proteins and their annotated locations for NP_001013175.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091271
      UniProtKB/TrEMBL
      A0A8I6A0P0, Q5BJZ3
      Related
      ENSRNOP00000029578.3, ENSRNOT00000033627.5
      Conserved Domains (4) summary
      PRK09424
      Location:57 → 587
      pntA; NAD(P) transhydrogenase subunit alpha; Provisional
      cd05304
      Location:57 → 432
      Rubrum_tdh; Rubrum transdehydrogenase NAD-binding and catalytic domains
      pfam02233
      Location:622 → 1079
      PNTB; NAD(P) transhydrogenase beta subunit
      pfam12769
      Location:502 → 587
      PNTB_4TM; 4TM region of pyridine nucleotide transhydrogenase, mitoch

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      53144157..53237857 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281783.1 → XP_063137853.1  NAD(P) transhydrogenase, mitochondrial isoform X4

      UniProtKB/TrEMBL
      A0A8I6AC81, A0A8I6ALS9

    2. XM_008760774.3 → XP_008758996.1  NAD(P) transhydrogenase, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_008758996.1

      UniProtKB/TrEMBL
      A0A8I6A0P0, Q5BJZ3
      Conserved Domains (4) summary
      PRK09424
      Location:57 → 587
      pntA; NAD(P) transhydrogenase subunit alpha; Provisional
      cd05304
      Location:57 → 432
      Rubrum_tdh; Rubrum transdehydrogenase NAD-binding and catalytic domains
      pfam02233
      Location:622 → 1079
      PNTB; NAD(P) transhydrogenase beta subunit
      pfam12769
      Location:502 → 587
      PNTB_4TM; 4TM region of pyridine nucleotide transhydrogenase, mitoch

    3. XM_006231968.5 → XP_006232030.1  NAD(P) transhydrogenase, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_006232030.1

      UniProtKB/TrEMBL
      A0A8I6A0P0, Q5BJZ3
      Conserved Domains (4) summary
      PRK09424
      Location:57 → 587
      pntA; NAD(P) transhydrogenase subunit alpha; Provisional
      cd05304
      Location:57 → 432
      Rubrum_tdh; Rubrum transdehydrogenase NAD-binding and catalytic domains
      pfam02233
      Location:622 → 1079
      PNTB; NAD(P) transhydrogenase beta subunit
      pfam12769
      Location:502 → 587
      PNTB_4TM; 4TM region of pyridine nucleotide transhydrogenase, mitoch

    4. XM_006231969.5 → XP_006232031.1  NAD(P) transhydrogenase, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_006232031.1

      UniProtKB/TrEMBL
      A0A8I6A0P0, Q5BJZ3
      Conserved Domains (4) summary
      PRK09424
      Location:57 → 587
      pntA; NAD(P) transhydrogenase subunit alpha; Provisional
      cd05304
      Location:57 → 432
      Rubrum_tdh; Rubrum transdehydrogenase NAD-binding and catalytic domains
      pfam02233
      Location:622 → 1079
      PNTB; NAD(P) transhydrogenase beta subunit
      pfam12769
      Location:502 → 587
      PNTB_4TM; 4TM region of pyridine nucleotide transhydrogenase, mitoch

    5. XM_063281785.1 → XP_063137855.1  NAD(P) transhydrogenase, mitochondrial isoform X4

      UniProtKB/TrEMBL
      A0A8I6AC81, A0A8I6ALS9
      Related
      ENSRNOP00000090631.1, ENSRNOT00000108201.2

    6. XM_006231972.5 → XP_006232034.1  NAD(P) transhydrogenase, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_006232034.1

      UniProtKB/TrEMBL
      A0A8I6A0P0, Q5BJZ3
      Conserved Domains (4) summary
      PRK09424
      Location:57 → 587
      pntA; NAD(P) transhydrogenase subunit alpha; Provisional
      cd05304
      Location:57 → 432
      Rubrum_tdh; Rubrum transdehydrogenase NAD-binding and catalytic domains
      pfam02233
      Location:622 → 1079
      PNTB; NAD(P) transhydrogenase beta subunit
      pfam12769
      Location:502 → 587
      PNTB_4TM; 4TM region of pyridine nucleotide transhydrogenase, mitoch

    7. XM_063281784.1 → XP_063137854.1  NAD(P) transhydrogenase, mitochondrial isoform X4

      UniProtKB/TrEMBL
      A0A8I6AC81, A0A8I6ALS9

    8. XM_006231971.5 → XP_006232033.1  NAD(P) transhydrogenase, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_006232033.1

      UniProtKB/TrEMBL
      A0A8I6A0P0, Q5BJZ3
      Conserved Domains (4) summary
      PRK09424
      Location:57 → 587
      pntA; NAD(P) transhydrogenase subunit alpha; Provisional
      cd05304
      Location:57 → 432
      Rubrum_tdh; Rubrum transdehydrogenase NAD-binding and catalytic domains
      pfam02233
      Location:622 → 1079
      PNTB; NAD(P) transhydrogenase beta subunit
      pfam12769
      Location:502 → 587
      PNTB_4TM; 4TM region of pyridine nucleotide transhydrogenase, mitoch

    9. XM_006231970.5 → XP_006232032.1  NAD(P) transhydrogenase, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_006232032.1

      UniProtKB/TrEMBL
      A0A8I6A0P0, Q5BJZ3
      Conserved Domains (4) summary
      PRK09424
      Location:57 → 587
      pntA; NAD(P) transhydrogenase subunit alpha; Provisional
      cd05304
      Location:57 → 432
      Rubrum_tdh; Rubrum transdehydrogenase NAD-binding and catalytic domains
      pfam02233
      Location:622 → 1079
      PNTB; NAD(P) transhydrogenase beta subunit
      pfam12769
      Location:502 → 587
      PNTB_4TM; 4TM region of pyridine nucleotide transhydrogenase, mitoch

    10. XM_039102256.2 → XP_038958184.1  NAD(P) transhydrogenase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I6A0P0, A0A8I6AQG5
      Related
      ENSRNOP00000085139.2, ENSRNOT00000103489.2
      Conserved Domains (2) summary
      PRK09424
      Location:112 → 642
      pntA; Re/Si-specific NAD(P)(+) transhydrogenase subunit alpha
      pfam02233
      Location:677 → 1134
      PNTB; NAD(P) transhydrogenase beta subunit

    11. XM_039102257.2 → XP_038958185.1  NAD(P) transhydrogenase, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A0A8I6A0P0
      Conserved Domains (2) summary
      PRK09424
      Location:112 → 578
      pntA; Re/Si-specific NAD(P)(+) transhydrogenase subunit alpha
      pfam02233
      Location:613 → 1070
      PNTB; NAD(P) transhydrogenase beta subunit
    Nucleotide Protein Strain
    Heading Accession and Version

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