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    Tcta T-cell leukemia translocation altered [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306587, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tctaprovided by RGD
    Official Full Name
    T-cell leukemia translocation alteredprovided by RGD
    Primary source
    RGD:1359333
    See related
    EnsemblRapid:ENSRNOG00000048237 AllianceGenome:RGD:1359333
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in negative regulation of osteoclast differentiation and osteoclast fusion. Predicted to be located in membrane. Orthologous to human TCTA (T cell leukemia translocation altered). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 333.3), Muscle (RPKM 196.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tcta in Genome Data Viewer
    Location:
    8q32
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (117867153..117871132, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (108988588..108992324, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (117079094..117082338, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene dystroglycan 1 Neighboring gene small nuclear ribonucleoprotein D2 polypeptide, pseudogene 3 Neighboring gene nicolin 1, tubulin polyglutamylase complex subunit Neighboring gene aminomethyltransferase Neighboring gene U6 snRNA-associated Sm-like protein LSm3 Neighboring gene ras homolog family member A Neighboring gene ribosomal protein S15a, pseudogene 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of TCTA, a gene located at the site of a t(1;3) translocation. Aplan PD, et al. Cancer Res, 1995 May 1. PMID 7728759
    2. T-cell leukemia translocation-associated gene (TCTA) protein is required for human osteoclastogenesis. Kotake S, et al. Bone, 2009 Oct. PMID 19560569
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in negative regulation of osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in osteoclast fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in osteoclast fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    T-cell leukemia translocation-altered gene protein homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014005.2 → NP_001014027.1  T-cell leukemia translocation-altered gene protein homolog isoform 2

      See identical proteins and their annotated locations for NP_001014027.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q5XIF1
      UniProtKB/TrEMBL
      A6I345
      Conserved Domains (1) summary
      pfam15128
      Location:15 → 106
      T_cell_tran_alt; T-cell leukemia translocation-altered

    2. NM_001401234.1 → NP_001388163.1  T-cell leukemia translocation-altered gene protein homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6I346

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      117867153..117871132 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008766514.4 → XP_008764736.3  T-cell leukemia translocation-altered gene protein homolog isoform X1

    2. XM_039081328.2 → XP_038937256.2  T-cell leukemia translocation-altered gene protein homolog isoform X4

      Related
      ENSRNOP00000110525.1, ENSRNOT00000075241.3

    3. XM_039081327.2 → XP_038937255.2  T-cell leukemia translocation-altered gene protein homolog isoform X3

    4. XM_039081326.2 → XP_038937254.2  T-cell leukemia translocation-altered gene protein homolog isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XIF1.1 GenPept UniProtKB/Swiss-Prot:Q5XIF1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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