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    Ap4s1 adaptor related protein complex 4 subunit sigma 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366618, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ap4s1provided by RGD
    Official Full Name
    adaptor related protein complex 4 subunit sigma 1provided by RGD
    Primary source
    RGD:1311990
    See related
    EnsemblRapid:ENSRNOG00000005765 AllianceGenome:RGD:1311990
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in vesicle-mediated transport. Predicted to be part of AP-4 adaptor complex. Predicted to be active in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 52. Orthologous to human AP4S1 (adaptor related protein complex 4 subunit sigma 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 181.1), Heart (RPKM 149.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ap4s1 in Genome Data Viewer
    Location:
    6q23
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (74863742..74916907)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (69133403..69174488)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (72461977..72502717)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor like GTPase 1, pseudogene 1 Neighboring gene cochlin Neighboring gene striatin 3 Neighboring gene uncharacterized LOC120103536 Neighboring gene HECT domain E3 ubiquitin protein ligase 1 Neighboring gene uncharacterized LOC134479181

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. AP-4, a novel protein complex related to clathrin adaptors. Dell'Angelica EC, et al. J Biol Chem, 1999 Mar 12. PMID 10066790
    2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC187750

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-4 adaptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    AP-4 complex subunit sigma-1
    Names
    adaptor-related protein complex 4, sigma 1 subunit
    adaptor-related protein complex AP-4, sigma 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130999.2 → NP_001124471.1  AP-4 complex subunit sigma-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A0G2K410
      Related
      ENSRNOP00000102365.1, ENSRNOT00000160575.1
      Conserved Domains (1) summary
      cd14832
      Location:3 → 140
      AP4_sigma; AP-4 complex subunit sigma

    2. NM_001428792.1 → NP_001415721.1  AP-4 complex subunit sigma-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6HBH4, B0BN62

    RNA

    1. NR_190496.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      74863742..74916907
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262181.1 → XP_063118251.1  AP-4 complex subunit sigma-1 isoform X2

      Related
      ENSRNOP00000072858.3, ENSRNOT00000090716.3

    2. XM_063262180.1 → XP_063118250.1  AP-4 complex subunit sigma-1 isoform X1

      UniProtKB/TrEMBL
      A6HBH4

    RNA

    1. XR_010052130.1 RNA Sequence

    2. XR_010052131.1 RNA Sequence

    3. XR_010052128.1 RNA Sequence

    4. XR_010052127.1 RNA Sequence

    5. XR_010052129.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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