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    Coq6 coenzyme Q6 monooxygenase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299195, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Coq6provided by RGD
    Official Full Name
    coenzyme Q6 monooxygenaseprovided by RGD
    Primary source
    RGD:1311149
    See related
    EnsemblRapid:ENSRNOG00000011164 AllianceGenome:RGD:1311149
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable oxidoreductase activity. Predicted to be involved in ubiquinone biosynthetic process. Predicted to be located in mitochondrial inner membrane. Predicted to be part of ubiquinone biosynthesis complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 6. Orthologous to human COQ6 (coenzyme Q6, monooxygenase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 234.9), Adrenal (RPKM 229.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Coq6 in Genome Data Viewer
    Location:
    6q31
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (109738934..109750315)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (104007814..104019888)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (108076393..108087782)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene prostaglandin reductase 2 Neighboring gene zinc finger protein 410 Neighboring gene FAM161 centrosomal protein B Neighboring gene ectonucleoside triphosphate diphosphohydrolase 5 Neighboring gene basal body orientation factor 1 Neighboring gene ring finger protein 113A2 Neighboring gene aldehyde dehydrogenase 6 family, member A1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 4-hydroxy-3-all-trans-hexaprenylbenzoate oxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ubiquinone biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquinone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extrinsic component of mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquinone biosynthesis complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
    Names
    coenzyme Q10 monooxygenase 6
    coenzyme Q6 homolog, monooxygenase
    NP_001011983.1
    XP_038967955.1
    XP_038967956.1
    XP_063117806.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011983.1 → NP_001011983.1  ubiquinone biosynthesis monooxygenase COQ6, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001011983.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079342
      UniProtKB/Swiss-Prot
      Q68FU7
      UniProtKB/TrEMBL
      A6JDV5
      Related
      ENSRNOP00000014914.5, ENSRNOT00000014913.8
      Conserved Domains (2) summary
      TIGR01988
      Location:57 → 475
      Ubi-OHases; Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family
      cl21454
      Location:57 → 471
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      109738934..109750315
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112028.2 → XP_038967956.1  ubiquinone biosynthesis monooxygenase COQ6, mitochondrial isoform X3

      Conserved Domains (1) summary
      cl21454
      Location:57 → 269
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. XM_063261736.1 → XP_063117806.1  ubiquinone biosynthesis monooxygenase COQ6, mitochondrial isoform X1

    3. XM_039112027.2 → XP_038967955.1  ubiquinone biosynthesis monooxygenase COQ6, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A8I6AN07
      Related
      ENSRNOP00000094755.1, ENSRNOT00000107126.2
      Conserved Domains (1) summary
      cl21454
      Location:64 → 407
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68FU7.1 GenPept UniProtKB/Swiss-Prot:Q68FU7

    Gene LinkOut

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