Cenpx centromere protein X [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cenpxprovided by RGD
Official Full Name: centromere protein Xprovided by RGD
Primary source: RGD:1590057
See related: EnsemblRapid:ENSRNOG00000090204 AllianceGenome:RGD:1590057
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Stra13
Summary: Predicted to enable DNA binding activity. Predicted to contribute to double-stranded DNA binding activity. Predicted to be involved in interstrand cross-link repair; replication fork processing; and resolution of meiotic recombination intermediates. Predicted to be located in chromatin. Predicted to be part of FANCM-MHF complex; Fanconi anaemia nuclear complex; and inner kinetochore. Orthologous to human CENPX (centromere protein X). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 76.6), Brain (RPKM 50.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (106489796..106492637, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (105991469..105994310, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (109890904..109893804, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
contributes_to double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in interstrand cross-link repair	ISO Inferred from Sequence Orthology more info
involved_in replication fork processing	ISO Inferred from Sequence Orthology more info
involved_in resolution of meiotic recombination intermediates	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of FANCM-MHF complex	ISO Inferred from Sequence Orthology more info
part_of Fanconi anaemia nuclear complex	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
part_of inner kinetochore	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: centromere protein X

Names: stimulated by retinoic acid 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398950.1 → NP_001385879.1 centromere protein X isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A6HLI2

Related

ENSRNOP00000106628.1, ENSRNOT00000136012.1

Conserved Domains (1) summary

pfam09415
Location:9 → 77

CENP-X; CENP-S associating Centromere protein X
NM_001398953.1 → NP_001385882.1 centromere protein X isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A6HLI3

Related

ENSRNOP00000104041.1, ENSRNOT00000171484.1

Conserved Domains (1) summary

pfam09415
Location:9 → 106

CENP-X; CENP-S associating Centromere protein X