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    Tril TLR4 interactor with leucine-rich repeats [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362364, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trilprovided by RGD
    Official Full Name
    TLR4 interactor with leucine-rich repeatsprovided by RGD
    Primary source
    RGD:1310827
    See related
    EnsemblRapid:ENSRNOG00000026941 AllianceGenome:RGD:1310827
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310827
    Summary
    Predicted to enable lipopolysaccharide binding activity. Predicted to be involved in regulation of cytokine production involved in immune response and toll-like receptor 4 signaling pathway. Predicted to be part of lipopolysaccharide receptor complex. Predicted to be active in extracellular matrix and extracellular space. Orthologous to human TRIL (TLR4 interactor with leucine rich repeats). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See Tril in Genome Data Viewer
    Location:
    4q24
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (84252781..84257626, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (82922327..82927172, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (83967695..83972540, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene cAMP responsive element binding protein 5 Neighboring gene uncharacterized LOC134486769 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene carboxypeptidase, vitellogenic-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain. Carpenter S, et al. J Immunol, 2009 Sep 15. PMID 19710467
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Reports data for human and mouse TRIL
      Title: TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables lipopolysaccharide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipopolysaccharide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cytokine production involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytokine production involved in immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in toll-like receptor 4 signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in toll-like receptor 4 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of lipopolysaccharide receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of lipopolysaccharide receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    TLR4 interactor with leucine rich repeats

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034010.2 → NP_001029182.1  TLR4 interactor with leucine rich repeats precursor

      See identical proteins and their annotated locations for NP_001029182.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q496Z2
      UniProtKB/TrEMBL
      A6K0U0
      Related
      ENSRNOP00000037327.1, ENSRNOT00000036951.4
      Conserved Domains (6) summary
      smart00060
      Location:589 → 661
      FN3; Fibronectin type 3 domain
      cd00116
      Location:22 → 313
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:327 → 340
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:85 → 108
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:229 → 289
      LRR_8; Leucine rich repeat
      cl15307
      Location:359 → 406
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      84252781..84257626 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q496Z2.1 GenPept UniProtKB/Swiss-Prot:Q496Z2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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