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    Rnf207 ring finger protein 207 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 691246, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rnf207provided by RGD
    Official Full Name
    ring finger protein 207provided by RGD
    Primary source
    RGD:1586262
    See related
    EnsemblRapid:ENSRNOG00000033722 AllianceGenome:RGD:1586262
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable Hsp70 protein binding activity and transmembrane transporter binding activity. Predicted to be involved in positive regulation of gene expression; regulation of cardiac muscle contraction; and regulation of heart looping. Predicted to be active in perinuclear region of cytoplasm. Orthologous to human RNF207 (ring finger protein 207). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 152.9) and Lung (RPKM 8.3) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rnf207 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (168098074..168112585, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (162815351..162828325, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (169486253..169500451, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene hes family bHLH transcription factor 3 Neighboring gene isoprenylcysteine carboxyl methyltransferase Neighboring gene ribosomal protein L22 Neighboring gene uncharacterized LOC120103139 Neighboring gene chromodomain helicase DNA binding protein 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RING finger protein RNF207, a novel regulator of cardiac excitation. Roder K, et al. J Biol Chem, 2014 Dec 5. PMID 25281747, Free PMC Article
    2. RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1. Yuan L, et al. Cardiovasc Res, 2023 Mar 17. PMID 35352799
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Hsp70 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cardiac muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of heart looping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RING finger protein 207; ring finger protein 207

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431299.1 → NP_001418228.1  ring finger protein 207 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      D4A306

    2. NM_001431300.1 → NP_001418229.1  ring finger protein 207 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    3. NM_001431301.1 → NP_001418230.1  ring finger protein 207 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      168098074..168112585 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039111530.2 → XP_038967458.1  RING finger protein 207 isoform X2

      Conserved Domains (2) summary
      cd16558
      Location:22 → 64
      RING-HC_RNF207; RING finger, HC subclass, found in RING finger protein 207 (RNF207) and similar proteins
      cd19814
      Location:97 → 150
      Bbox1_RNF207-like; B-box-type 1 zinc finger found in RING finger protein 207 (RNF207) and similar proteins

    2. XM_008764392.4 → XP_008762614.1  RING finger protein 207 isoform X4

      Conserved Domains (2) summary
      cd00162
      Location:25 → 65
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam00643
      Location:100 → 145
      zf-B_box; B-box zinc finger

    3. XM_039111532.2 → XP_038967460.1  RING finger protein 207 isoform X5

      Conserved Domains (3) summary
      COG1196
      Location:201 → 464
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd16558
      Location:22 → 64
      RING-HC_RNF207; RING finger, HC subclass, found in RING finger protein 207 (RNF207) and similar proteins
      cd19814
      Location:97 → 150
      Bbox1_RNF207-like; B-box-type 1 zinc finger found in RING finger protein 207 (RNF207) and similar proteins

    4. XM_039111531.2 → XP_038967459.1  RING finger protein 207 isoform X3

      Conserved Domains (3) summary
      smart00502
      Location:202 → 321
      BBC; B-Box C-terminal domain
      cd16558
      Location:22 → 64
      RING-HC_RNF207; RING finger, HC subclass, found in RING finger protein 207 (RNF207) and similar proteins
      cd19814
      Location:97 → 150
      Bbox1_RNF207-like; B-box-type 1 zinc finger found in RING finger protein 207 (RNF207) and similar proteins

    5. XM_001075996.8 → XP_001075996.1  RING finger protein 207 isoform X1

      Related
      ENSRNOP00000047020.3, ENSRNOT00000046552.7
      Conserved Domains (3) summary
      cd00162
      Location:25 → 65
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam00643
      Location:100 → 145
      zf-B_box; B-box zinc finger
      cl23765
      Location:202 → 321
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    6. XM_063288668.1 → XP_063144738.1  RING finger protein 207 isoform X8

    7. XM_039111535.2 → XP_038967463.1  RING finger protein 207 isoform X7

      Conserved Domains (3) summary
      cd00162
      Location:25 → 63
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cd19814
      Location:97 → 150
      Bbox1_RNF207-like; B-box-type 1 zinc finger found in RING finger protein 207 (RNF207) and similar proteins
      cl17238
      Location:22 → 64
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    8. XM_039111534.2 → XP_038967462.1  RING finger protein 207 isoform X6

      Conserved Domains (4) summary
      smart00502
      Location:202 → 321
      BBC; B-Box C-terminal domain
      cd00162
      Location:25 → 63
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cd19814
      Location:97 → 150
      Bbox1_RNF207-like; B-box-type 1 zinc finger found in RING finger protein 207 (RNF207) and similar proteins
      cl17238
      Location:22 → 64
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    Nucleotide Protein Strain
    Heading Accession and Version

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